depressionmechanism of actionOver the last two decades, the dissociative anaesthetic agent ketamine, an uncompetitive N-Methyl-D-Aspartate (NMDA) receptor antagonist, has emerged as a novel therapy for treatment-resistant depression (TRD), demonstrating rapid and robust antidepressant effects within hours...
Jeff Winograd, who's lived with depression for more than 25 years, says ketamine treatment saved his life. Jeff Winograd couldn’t get off his couch. He’d hit rock bottom with the depression he’d had since he was 20. It felt paralyzing. “I was suicidal,” he says. “I would sit...
Ketamine for depression: where do we go from here? Since publication of the first randomized controlled trial describing rapid antidepressant effects of ketamine, several reports have confirmed the potentia... MAH Rot,Carlos A. Zarate Jr.,DS Charney,... - 《Biological Psychiatry》 被引量: 365...
The approval of ketamine for treatment-resistant depression has created a model for a novel class of rapid-acting glutamatergic antidepressants. Recent research into other novel rapid-acting antidepressants - most notably serotonergic psychedelics (SPs) - has also proven promising. Presently, the mechanis...
Suicide and depression rating scores (Scale for Suicidal Ideation, SSI; Montgomery-sberg Depression Rating Scale, MADRS) were obtained at baseline, on treatment days, on days 14 and 42 (primary endpoint). Results: All patients experienced benefit with ketamine. SSI scores diminished by 84% from...
The monoamine hypothesis of depression was developed in the 1950s based on two primary lines of evidence: 1) the effects of reserpine on monoamines; and 2) the findings of different studies on the antidepressant properties of agents with different mechanisms of action, such as monoamine oxidase ...
New treatments for depression are needed that act rapidly and also have sustained effects. Ketamine accomplishes this, but toxic side effects limit its long-term use. Scientists haven’t understood how ketamine was able to do both, which hindered drug development. ...
This trial successfully masked treatment allocation in patients with moderate-to-severe depression using surgical anesthesia. Although this masking strategy is impractical for most placebo-controlled trials, future studies of novel antidepressants with acute psychoactive effects should make efforts to fully ...
This is often the case when using ketamine for depression as well, which is why people with severe depression usually need to keep going back to maintain improvements. Recent studies are showing when paired with psychotherapy, ketamine can be incredibly effective with longer lasting gains so ...
Comparative efficacy of racemic ketamine and esketamine for depression: A systematic review and meta-analysis Background: Ketamine appears to have a therapeutic role in certain mental disorders, most notably depression. However, the comparative performance of diffe... Bahji, AneesVazquez, Gustavo H.Za...