Results showed that the addition of levetiracetam decreased weekly seizure rates by 50% or more in 72.2% of patients compared with 45.2% of those receiving usual therapy alone (P< .001) Seizure-free rates were also significantly increased in the levetiracetam group (24.1% vs 7.1%;P= .004)....
Although the molecular significance of levetiracetam binding to synaptic vesicle protein SV2A is not understood, levetiracetam and related analogs showed a rank order of affinity for SV2A which correlated with the potency of their antiseizure activity in audiogenic seizure-prone mice. These findings ...