KEAP1 (D6B12) Rabbit mAb #8047 20 µl WB, IF H M R 60-64 Rabbit IgG NRF2 (D1Z9C) XP® Rabbit mAb #12721 20 µl WB, IP, IF, F, ChIP H M Mk 97-100 Rabbit IgG HO-1 (E3F4S) Rabbit mAb #43966 20 µl WB, IP H M R 28 Rabbit IgG NQO1 (D6H3A) Rabbit...
作者确定了糖酵解酶PGK1的小分子抑制剂,并揭示了糖酵解和NRF2信号传导之间的直接联系。PGK1的抑制导致活性代谢物MGx的积累,其选择性地修饰KEAP1以便在近端半胱氨酸和精氨酸残基(MICA)之间形成甲基咪唑交联;该翻译后修饰的过程导致KEAP1的二聚化、NRF2的积累和NRF2转录程序的激活。总的来说,在糖酵解和KEAP1-NRF2...
WB-Western Blotting Species Cross-Reactivity Key: H-Human M-Mouse R-Rat Related Products NRF2 (D1Z9C) XP® Rabbit mAb #12721 20 µl KEAP1 (D6B12) Rabbit mAb #8047 100 µl Total NRF2 Matched Antibody Pair #39728 1 Kit Product Information Product Usage Information Applicati...
作者确定了糖酵解酶PGK1的小分子抑制剂,并揭示了糖酵解和NRF2信号传导之间的直接联系。PGK1的抑制导致活性代谢物MGx的积累,其选择性地修饰KEAP1以便在近端半胱氨酸和精氨酸残基(MICA)之间形成甲基咪唑交联;该翻译后修饰的过程导致KEAP1的二聚化、NRF2的积累和NRF2转录程序的激活。总的来说,在糖酵解和KEAP1-NRF2...
Subsequently, retinal mRNA and protein expression levels of KEAP1, NRF2, and SOD were quantified using real-time polymerase chain reaction (RT-PCR) and Western blot (WB) analysis. The RT-PCR and WB results demonstrated that TBHQ could activate NRF2, induce KEAP1 degradation, and enhance the ...
1.本技术涉及keap1-nrf2-are信号通路技术领域,尤其涉及靶向keap1-nrf2-are信号通路的化合物、制备方法及其应用。 背景技术: 2.氧化应激对于所有生命系统都是至关重要的,尤其是其广泛参与神经系统的病理生理变化过程,例如脑缺血再灌注损伤是氧化应激的急性表现,慢性氧化应激是神经性退行性疾病发生发展的重要原因。
However, the increased activation of Nrf2 is also known to promote tumor growth and metastasis. Mutations in both KEAP1 and Nrf2 were found in various solid tumor types. Protocols Product Specific Protocols WB protocol for KEAP1 antibody 60027-1-Ig Download protocol IHC protocol for KEAP1 ...
The RT-PCR and WB results demonstrated that TBHQ could activate NRF2, induce KEAP1 degradation, and enhance the expression of the antioxidant SOD. In summary, the modulation of KEAP1-NRF2 and it downstream SOD expression could alter the retinal antioxidant capacity and influence the development of...
可以参考一下，以下都是针对WB:1.santa的C-20 不可靠，不能正确指示Nrf2的位置;2.santa的H-300可用...
Tested Applications WB, ELISA Application Description Tested Reactivity Human Immunogen KEAP1 fusion protein Ag32512 种属同源性预测 Host / Isotype Rabbit / IgG Class Polyclonal Type Antibody Full Name kelch-like ECH-associated protein 1 Synonyms Cytosolic inhibitor of Nrf2, INrf2, KEAP1, Kelch like...