Our study provides new insight into the role of KEAP1 mutations in promoting immune evasion and suggests a path to novel immune-based therapeutic strategies for KEAP1 mutant lung cancer. Statement of significance This study establishes that tumor-intrinsic KEAP1 mutations contribute to immune evasion...
Fig 2. STK11and KEAP1 Co-mutation Promotes CellGrowth, Independent of KRAS MutationStatus Fig 3. KEAP1 Re-expression Disrupts Growth of STK11/KEAP1 Co-mutant Lung AdenocarcinomaCells 3.STK11/KEAP1共突变细胞具有不同的转录谱那么,STK11或KEAP1中的选择性突变如何改变癌细胞的转录谱?共突变细胞的转...
First, we discovered that KEAP1/NRF2‐mutant lung cancer presented APOBEC‐mediated mutational signatures, impaired tumor angiogenesis, elevated hypoxic stress and deficient immune‐cell infiltrates. Second, gene expression‐based subtyping revealed three molecular subsets of KEAP1/NRF2‐mutant lung ...
本文主要参考Triparna Sen, et al. Metabolic profile and therapeutic vulnerabilities of multi-omic characterization of KRAS/STK11/KEAP1 co-mutant non–small cell lung cancer (NSCLC). 2024 ASCO Abstract #8576. J Clin Oncol 42, 2024...
[35,36]. However, a different study revealed that combining CB839 with anti-PD-1 treatment inhibited the clonal expansion and activation of CD8 + T cells in KEAP1 and STK11 double-mutant lung cancer, resulting in a loss of therapeutic benefit [37]. Therefore, the effect of single-...
The postoperative 5-year disease-free survival rate for patients with a mutant Keap1 tumor was slightly lower than for patients with Keap1 wild-type tumors (25% vs. 66%, P = 0.057).ConclusionsKeap1 gene mutations are likely to be associated with a worse prognosis and lower postoperative ...
7. K. C. Arbouret al., Effects of Co-occurring Genomic Alterations on Outcomes in Patients with KRAS-Mutant Non-Small Cell Lung Cancer.Clin Cancer Res24, 334-340 (2018). 8. N. Cancer Genome Atlas Research, Comprehensiv...
et al. LKB1 and KEAP1/NRF2 pathways cooperatively promote metabolic reprogramming with enhanced glutamine dependence in KRAS-mutant lung adenocarcinoma. Cancer Res. 79, 3251–3267 (2019). Article CAS PubMed PubMed Central Google Scholar Hamada, S. et al. Nrf2 activation sensitizes K-Ras mutant...
The KEAP1 knocked-down MDA-MB-435 cells were further transfected with wild-type and mutant KEAP1, and a panel of NF-κB-targeting gene expression was examined by qRT-PCR. Clinical Association between IKKβ Expression, KEAP1 and CUL3 Expression, and Survival in Breast Cancer Patients To ...
6. Best SA, Ding S, Kersbergen A, Dong X, Song JY, Xie Y, et al. Distinct initiating events underpin the immune and metabolic heterogeneity of kras-mutant lung adenocarcinoma. Nat Commun. 2019; 10: 4190. 7. K...