Featured Product KD/KO Validated KEAP1 Polyclonal antibody KEAP1 Polyclonal Antibody for WB, IHC, IF/ICC, IP, ELISA Cat No. 10503-2-AP Publications(719) Host / Isotype Rabbit / IgG Reactivity human, mouse and More (6) Applications WB, IHC, IF/ICC, IP, ELISA and More (3) ...
图3:连接部分的筛选 为了证实DGY-06-177-pk2介导的BRD4降解依赖于KEAP1,研究人员比较了其在未敲除(亲代)和敲除KEAP1(KEAP1KD)的OVCAR8细胞中的降解活性。在亲代OVCAR8细胞中,DGY-06-177-pk2在16 h后诱导BRD4的显著降解,在1 μM时降解活性达到最大。相...
KD/KO See 3 publications below WB See 94 publications below IHC See 8 publications below IF See 18 publications below IP See 2 publications below CoIP See 3 publications below 产品信息 60027-1-Ig targets KEAP1 in WB, IHC, IF/ICC, IP, CoIP, ELISA applications and shows reactivity with hum...
产品活性:Keap1-Nrf2-IN-3 是一种KEAP1:NRF2蛋白?蛋白相互作用抑制剂,并且对 KEAP1 蛋白质的Kd值为 2.5 nM。 研究领域:NF-κB 作用靶点:Keap1-Nrf2 相关产品:ML385|Resveratrol|4-Octyl Itaconate|Curcumin|Sulforaphane|TBHQ|Luteolin|Bardoxolone methyl|Dimethyl fumarate|KI696|Omaveloxolone|Oltipraz|Brusatol...
本文采用心脏特异性转基因(TG)和基因敲除(KD)小鼠模型,研究肿瘤易感基因101(Tsg101)在对抗I/R触发的氧化应激中的心脏保护作用。RNA测序和生物信息学数据揭示了Tsg101 TG心脏中大多数上调的基因是由Nrf2转录的。因此,药物抑制Nrf2抵消Tsg101引起心脏保护作用。机...
KEAP1 (Kelch-1ike ECH- associated protein l,)是指Kelch 样环氧氯丙烷相关蛋白 1,由 Itoh 等 [1] 通过酵 母双杂交方式分离得到的相对分子量为 69 kD的蛋白。 KEAP1含有5个结构域,分别为N端结构域NTR(N-terminal region)、干预区IVR(intervening region)、BTB(Broad complex, Tramtrack and Bric-à-Brac...
Nrf2 was activated in the thyroid of Keap1(KD)mice. Despite a known stimulatory effect of Nrf2 on thyroglobulin (Tg) gene transcription and Tg protein abundance, the expression levels were decreased in the thyroid of Keap1(KD)mice. No clear patterns were observed in the expression profiles of...
KD/KO See 3 publications below WB See 94 publications below IHC See 8 publications below IF See 18 publications below IP See 2 publications below CoIP See 3 publications below Product Information 60027-1-Ig targets KEAP1 in WB, IHC, IF/ICC, IP, CoIP, ELISA applications and shows reactivity...
高分子量蛋白Marker(43-200KD) Carprofen 质量规格:>99% 高分子量非变性电泳蛋白质Marker(66-669 kD) Carprofen 质量规格:HPLC>98%,标准品 碱性蛋白非变性电泳蛋白Marker Catharanthine 质量规格:>98%,分析标准品 宽分子量蛋白Marker(10-200KD) Albendazole 质量规格:>98%,标准品 公司简介 上海研生实业...
(IgD于1995年从人骨髓瘤蛋白中发现,分子量为175kD,主要由扁桃体、脾等处浆细胞产生,人血清中IgD浓度为3～40μg/ml,不到血清总Ig的1%,在个体发育中合成较晚。IgD铰链区很长,且对蛋白酶水解敏感,因此IgD半衰期很短,仅2.8天。血清中IgD确切的免疫功能尚不清楚。在B细胞分化到成熟B细胞阶段,除了表达SmIgD,抗原...