此外,研究人员发现KDM4A-AS1通过抑制AR/AR-Vs降解来增强CRPC对恩杂鲁胺的耐药性;通过将靶向KDM4A-AS1的反义寡核苷酸药物(ASO-KDM4A-AS1,10mg/kg)腹腔注射到异种移植小鼠体内,结果发现显著降低了对恩杂鲁胺耐药的肿瘤的生长。 Fig4. 靶向KDM4A-AS1的ASO药物可恢复恩杂鲁胺耐药性 总之,本研究结果表明KDM4A-AS...
Moreover, KDM4A-AS1 was found to enhance CRPC drug resistance to enzalutamide by repressing AR/AR-Vs degradation; antisense oligonucleotide drugs targeting KDM4A-AS1 significantly reduced the growth of tumors with enzalutamide resistance. Taken together, our results indicated that KDM4A-AS1 played an...
Elevated KDM4A-AS1 level was correlated to poor prognosis of HCC. Knockdown of KDM4A-AS1 inhibited the proliferation, migration, invasion and EMT of HCC cells. ILF3 bound to KDM4A-AS1 and AURKA. KDM4A-AS1 maintained the stability of AURKA mRNA by recruiting ILF3. E2F1 transcriptionally ...