Both chemical KDM1A inhibitors and gene manipulation can selectively reduce the viability of DNMT3A-KO cells through inducing cell apoptosis in vitro and in vivo. We clarified that the synthetic lethality is not only limited to the death mode, but also involved into tumour metastasis. ...
A: Analysis of the correlation between YTHDF2 and KDM1A expression in Gene Expression Omnibus data sets (https://www.ncbi.nlm.nih.gov/geo; accession numbers GSE45827, GSE70947, and GSE42568) and The Cancer Genome Atlas Breast Cancer. B and C: The mRNA and protein levels of KDM1A were...
(S683D) mutation. Cells were treated with CHX for the indicated times. Band intensity of KDM1A from western blots was quantified as described inFig. 1b(mean ± s.d.,n= 3 independent experiments, two-tailed Student’st-test).∗P< 0.01. (e) GSC11 or HFU-251 MG cells were treated ...