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Results are the mean±SD of at least three independent experiments; Irradiated cells are compared to non-irradiated cells in each condition. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001. Full size image Hypoxia modulates KDM3A and KDM6B expression in ESCC ...
Macrophage pyroptosis is a pivotal inflammatory mechanism in sepsis-induced lung injury, however, the underlying mechanisms remain inadequately elucidated. Lipopolysaccharides (LPS)/adenosine triphosphate (ATP)-stimulated macrophages and cecal ligation a
Full size image Table 1 Basic characteristics of NMIBC patients Full size table Genomic landscape of NMIBC in small Chinese cohort Genomic profiling revealed a high prevalence of alterations in TERT (55%), KDM6A (32.5%), KMT2D (32.5%), FGFR3(30%), PIK3CA (30%), TP53(27.5%), KMT2C ...
Histone demethylase LSD1 plays key roles during carcinogenesis, targeting LSD1 is becoming an emerging option for the treatment of cancers. Numerous LSD1 inhibitors have been reported to date, some of them such as TCP, ORY-1001, GSK-2879552, IMG-7289, IN
Full size image Table 1 Overview of LSD1/KDM1A inhibitors in clinical trials Full size table TCP (tranylcypromine) The tranylcypromine (abbreviated as TCP or PCPA), an inhibitor of monoamine oxidase (MAO) used in clinic for the treatment of depression [59,60], was identified as an irreversibl...
Mice in the sham group were subjected to laminectomy without contusion. Bladders were manually massaged twice daily until full voluntary or autonomic voiding was obtained, and antibiotic (penicillin sodium; North China Pharmaceutical, Shijiazhuang, China) was administered once daily for 3 days post...
Download: Download full-size image Figure 1. Expression of Kdm2b/Jhdm1b is up-regulated in leukemic stem cells. (A) KDM2B/JHDM1B is overexpressed at the RNA level in human AML, T-cell acute lymphoid leukemia (T-ALL), and B-cell acute lymphoid leukemia (B-ALL) compared with their norm...
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Because of the rare presentation of the latter form of the disease, little is known about how mis‑ sense changes in the KDM6A protein sequence impact protein function. Results: In this study, we use molecular mechanic and molecular dynamic simulations to enhance the annotation and ...