The human KCNMB3 gene islocated on a region of chromosome 3 (specifically 3q26.32) that is thoughtto be implicated in the pathogenesis of neurological abnormalities.RiaziBrinkman-MillsJohnsonNaylorMinoshimaKCNMBKCNMB
The KCNMB3 gene encodes one of a family of four auxiliary β subunits found in the mammalian genome that associate with Slo1 α subunits and regulate BK channel function. In humans, the KCNMB3 gene contains four N-terminal alternative exons that produce four functionally distinct β3 subunits, ...
The KCNMB3 gene encodes one of a family of four auxiliary β subunits found in the mammalian genome that associate with Slo1 α subunits and regulate BK ch... X Zeng,Xia, X.-M.,CJ Lingle - 《Journal of General Physiology》 被引量: 36发表: 2008年 ADKINS, A. W. H., From the Many...
The protein encoded by this gene is an auxiliary beta subunit which may partially inactivate or slightly decrease the activation time of MaxiK alpha subunit currents. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 22. 仅用于科研。不...
Synthetic peptide of human KCNMB3 Buffer System pH 7.4 PBS, 0.05% NaN3, 40% Glycerol Dilution Ratio WB: 1/500-1/1000 IHC: 1/50-1/100 Molecular Weight Calculated MW: 32 kDa; Observed MW: 32 kDa Clonality Polyclonal Antibody Gene Name KCNMB3 Conjugation Unconjugated Isoty...
Allelic association of a truncation mutation of the KCNMB3 gene with idiopathic generalized epilepsy. Am J Med Genet B Neuropsychiatr Genet 144B: 10 -13, 2007.Lorenz S, Heils A, Kasper JM, Sander T. Allelic association of a truncation mutation of the KCNMB3 gene with idiopathic generalized ...
Furthermore, the gene maps to a region containing a susceptibility factor for this disorder. Taken together, these data suggest that neurons expressing BK channels composed of the beta3b-V4 variant subunit may experience reduced levels of inhibition and may therefore play permissive roles in high ...
In humans, the KCNMB3 gene is comprised of 4 N-terminal alternative exons which produce 4 functionally distinct beta3 subunits, beta3a-d. Three variants, beta3a-c, display kinetically distinct inactivation behaviors. Description KCNMB3 Human Recombinant produced in E.Coli is a single, non-...