Full size image To further gain mechanistic insights into the unique substrate selectivity and hydroxylation pattern of PikCH238pAcF, we solved the crystal structures of 6-bound and 4-bound PikCH238pAcF (Supplementary Fig. 53). Similar to the substrate free PikCH238pAcF structure, in both struct...
Genotyping. DNA from all VIKING participants was quantitated using picogreen and diluted to 50 ng/μL; 4 μL were then used for genome-wide genotyping on the HumanOmniExpressExome-8 v1.2 BeadChip (Illumina), with Infinium chemistry18. DNA samples from two c.1750G > A; p....
3B–C). There was also an evident shift in the relative electrophoretic mobility (Mr) from the fully post-translationally modified form (≈125 kDa) of KV2.1 toward an Mr of ≈96 kDa, suggesting a deficit in the processing of the Kcnb1G379R variant into the mature, fully post-...
To confirm global differences in mRNA structure, circular dichroism (CD) was utilized. Both hERG-NT and hERG-CM CD profiles demonstrated RNA folded into A-form helices (noted by a positive peak at ∼260 nm and a negative peak at ∼210 nm) (12, 13) and difference in nucleic acid ...
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