The Roles of Ca21/NFAT Signaling Genes in Kawasaki Disease: Single- and Multiple-Risk Genetic Variants Wei Wang1*, Jiao Lou2*, Rong Zhong2, Yan-qi Qi1, Na Shen2, Xu-zai Lu3, Yu-jia Wang4, Qing Zhang1, Li Zou2, Jia-yu Duan2, Jun-tao Ke2, Xiao-ping Miao2 & Fang-qi Gong...
MATERIALS AND METHODS Subjects Children with KD were recruited from 12 tertiary academic hospitals in Korea that participated in the Korean Kawasaki Disease Genetics Consortium (KKDGC). Pediatricians diagnosed all KD patients according to the diagnostic criteria of the American Heart Association.19,20 ...
All patients met the criteria for the diagnostic guidelines of Kawasaki disease (http://www.kawasaki-disease.org/diagnostic/ index.html). A CAL was defined as the lumen diameter being at least 3 mm (4 mm in cases of the patients' age older than 5 y) or the internal diameter of one ...
Coronary artery aneurysm (CAA) formation is the major complication of KD and the leading cause of acquired cardiovascular disease among children. To identify susceptible loci that might predispose patients with KD to CAA formation, a genome-wide association screen was performed in a Taiwanese KD ...
Coxsackievirus A6 (CVA6) has recently emerged as the leading genotype linked to global outbreaks of atypical hand, foot, and mouth disease (HFMD) and/or herpangina [15,16,17]. In Thailand, CVA6 has driven recurring large-scale HFMD outbreaks since 2012, solidifying its role as a major path...