KAT8–IRF1 condensation promotes IRF1 K78 acetylation and binding to the CD247 (PD-L1) promoter and further enriches the transcription apparatus to promote transcription of PD-L1 mRNA. Based on the mechanism of KAT8–IRF1 condensate formation, we identified the 2142–R8 blocking peptide, which ...
KAT8–IRF1 condensation promotes IRF1 K78 acetylation and binding to the CD247 (PD-L1) promoter and further enriches the transcription apparatus to promote transcription of PD-L1 mRNA. Based on the mechanism of KAT8–IRF1 condensate formation, we identified the 2142–R8 blocking peptide, which ...
Disruption of KAT8–IRF1 Condensate Formation Reduces PD-L1 Expressiondoi:10.1158/2159-8290.CD-RW2023-042The histone acetyltransferase KAT8 transcriptionally upregulates PD-L1 through cocondensation with IRF1.Cancer Discovery
KAT8已报道可催化非组蛋白底物，研究人员发现KAT8可乙酰化IRF1 K78位点，凝聚体形成可增强催化速率约40倍，IRF1 K78ac可增强与PD-L1启动子结合能力。根据KAT8-IRF1凝聚体形成的结构基础，研究人员基于IRF1 N端与KAT8的特异性相互作用进行深入分析，发现IRF1的21-42位氨基酸是介导特异性互作的主要区域。进而研究人员...
KAT8已报道可催化非组蛋白底物,研究人员发现KAT8可乙酰化IRF1 K78位点,凝聚体形成可增强催化速率约40倍,IRF1 K78ac可增强与PD-L1启动子结合能力。 根据KAT8-IRF1凝聚体形成的结构基础,研究人员基于IRF1 N端与KAT8的特异性相互作用...