KAT8-IN-1 is a lysine (K) acetyltransferase 8 (KAT8) inhibitor, with IC50s of 141 μM (KAT8), 221 μM (KAT2B), 106 μM (KAT3B), respectively. KAT8 inhibits histone acetyltransferases (HATs), and could result in disease states, such as cancer or inflammatory diseases[1]. ...
KAT8 inhibitor may be used; a composition comprising a HAT1 inhibitor, wherein the HAT1 inhibitor is used in combination with a KAT8 inhibitor, may be used; or a composition comprising a KAT8 inhibitor, wherein the KAT8 inhibitor is used in combination with a HAT1 inhibitor, may be ...
in the placenta enhances mTSCs stemness and prevents differentiation32,33,34. Furthermore, the use of EX527 as a SIRT1 inhibitor has been shown to elevate acetylation levels of H4K1632,34(Fig.5a). To evaluate whether increase H4K16 acetylation could restore CDX2 expression...
Thus, our work identifies that KAT8 could serve as a potential clinically relevant biomarker and therapeutic target in patients with ESCC and that KAT8 inhibitor is a promising lead candidate for ESCC therapy. Graphical abstract Download: Download high-res image (191KB) Download: Download full-...
3G). In both HEK293T and PANC-1 cells, the HAT inhibitor MG149 inhibited KAT8-mediated acetylation of SEPP1, and the immunoprecipitated SEPP1 was decreased in the presence of MG149 (Fig. 3H). Similarly, KAT8 recombinant protein (rmKAT8) also mediated the acetylation of SEPP1 which was ...
[3] 1130 - First-in-class KAT6A/KAT6B inhibitor CTx-648 (PF-9363) demonstrates potent anti-tumor activity in ER+ breast cancer with KAT6A dysregulation. Retrieved Apr 10, 2021. From网页链接 @药明康德内容团队报道 免责声明:药明康德内容团队专注介绍全球生物医药健康研究进展。本文仅作信息交流之目的...
Therapy-related AML with t(8;16) may occur after either alkylating agent or topoisomerase II inhibitortherapy and usually has a short latency period. 【翻译】治疗相关的急性髓系白血病伴t(8;16)可发生于烷化剂或拓扑...
acetyltransferase anacardic acid bisubstrate breast cancer curcumin garcinol HAT histone HTATIP inhibitor DOI: 10.1042/BST20160081 被引量: 13 年份: 2016 收藏 引用 批量引用 报错 分享 全部来源 免费下载 求助全文 全文购买 国家科技图书文献中心 (权威机构) EBSCO 掌桥科研 Semantic Scholar Semantic Scholar ...
Alternatively, a composition containing a HAT1 inhibitor, the HAT1 inhibitor being used in combination with a KAT8 inhibitor, may be used. Alternatively, a composition containing a KAT8 inhibitor, the KAT8 inhibitor being used in combination with a HAT1 inhibitor, may be used.MIURA, NORIMASA...
KAT8 inhibitor may be used; a composition comprising a HAT1 inhibitor, wherein the HAT1 inhibitor is used in combination with a KAT8 inhibitor, may be used; or a composition comprising a KAT8 inhibitor, wherein the KAT8 inhibitor is used in combination with a HAT1 inhibitor, may be ...