There are some molecular subtypes with a higher chance of spontaneous remission such as AML with t(8;16)(p11.2;p13.3) resulting in KAT6A-CREBBP (alias MOZ/MYST3-CREBBP/CBP) fusion or with recently described t(8;22)(p11;13) resulting in KAT6A-EP300 fusion (alias MOZ/MYST3-p300).6 ...
KAT6A/B not only influences the expression pattern of other transcripts but is also dependent on epigenetic modulations, such as the regulation of the methylation of the promoter region, miRNAs, and lncRNAs. It has recently been discovered that theKAT6Bpromoter region is mediated by EZH2 and hype...