Kasugamycin, a new antibiotic. Antimicrob Agents Chemother 5: 753–757 (1965) 2. Ikeno S, Higashide K, Kinoshita N, Hamada M, Hori M. Correlation between the presence of kac, kasugamycin acetyltransferase gene, and the productivity of kasugamycin in Strepromyces. Actinomycetologica 10: 73–...
(ATCC. 15714 and 15715) or kasugamycin-producing variants and mutants thereof in an aqueous carbohydrate solution containing a nitrogenous nutrient under submerged aerobic conditions until substantial anti-bacterial activity is imparted to said solution and then recovering the antibiotic from the solution....
it has been suggested that the presence of m1G at nucleotide 745 could have an allosteric effect on antibiotic binding [42]. Similarly, inactivation of RlmAII, a homolog of RlmAIthat methylates G748 (m1G748), leads to low-level resistance to telithromycin and is a common mechanism of resis...
compounds are used for preparing semi-synthetic antibiotically active kasugamycin derivatives. For example, by reaction of compound (Ia) with (1) methyl acetamidate, and (2) 4-pyridinealdoxime or methyl-4-pyridinecarboximidate, in each case followed by catalytic hydrogenation to remove the carbo...
ALPHA-D-GLYCOSYL KASUGAMYCIN, ITS PRODUCTION AND ANTIBACTERIAL AGENT CONTAINING THE SAMEPURPOSE: To obtain the subject new antibiotic having a growth-inhibiting action of a disease injury microorganism and high safety and useful as an antibacterial agent, etc., for agriculture and horticulture, for ...
This new antibiotic is obtained by dissolving with heating kasugamycin having a chemical structure of formula II and produced by Streptomyces kasugaensis together with starch (e.g. dextrin) in water, adding sugar transferase (e.g. cyclomaltodextrin glucanotransferase) to the resultant solution, ...
Antibiotics application is a valuable measure to control this bacterial disease. However, microbial antibiotic resistance dramatically reduced antibiotic effectiveness. Identifying the resistance mechanism of Xoo to antibiotics and restoring antibiotic susceptibility is one of the crucial ways to solve this ...
kasuga -which comprise"; the aerobic cultivation of strain streptomycea kasugaspinus, its natural mutants and1 -variants in a nutrient medium having sources of car bon, nitrogen anrJ inorganic salts, followed by removal of mycelia produced and recovery of the antibiotic values in the known ways...
The hydrolysing agent used is hydrazine in an organic solvent such as a C 1 to C 4 alkanol. The inventive compounds are used for preparing semi-synthetic antibiotically active kasugamycin derivatives. For example, by reaction of compound (Ia) with (1) methyl acetamidate, and (2) 4-...