Kappa and lambda light chain mRNA in situ hybridization compared to flow cytometry and immunohistochemistry in B cell lymphomas. Diagn Pathol. 2014; 9 :144. doi: 10.1186/1746-1596-9-144. [ Cross Ref ]Rimsza LM, Day WA, McGinn S, et al. Kappa and lambda light chain mRNA in situ ...
κ(Kappa-LightChain)和λ(Lambda-LightChain)两兄弟 κ和λ是免疫球蛋白上的两条肽链。每个免疫球蛋白分子有两条相同的重链和两条相同的轻链。两条相同的轻链即为κ和λ ,可标记带有轻链的B淋巴细胞、浆细胞和免疫母细胞。 正常情况下轻链和重链的分泌是平衡的,二者可结合成完整的免疫球蛋白分子。淋巴细胞在发...
There are two types of immunoglobulin light chain produced in humans, designated kappa (κ) and lambda (λ). The quantification of serum FLC is used as an aid in the diagnosis and monitoring patients with Multiple Myeloma. Ratio FLC value (kappa FLC/lambda FLC) compared to reference ranges ...
参考文献: 1.MoghimiM, KashkooliBehrooziM,MaghbooliM,etal.Assoaition between abnormal serum free light chain sratioand known prognostic factorsin lyphoma;anephrologyview point[J].JRenal InjPrev,2016. 2.Jardin F, Delfau-Larue MH, Molina TJ,etal. Immunoglobulin heavy chain/ light chain pairmeasu...
Light Chains (Kappa, Lambda) XISHProbes - HistoSonda Kappa Light Chain,Useful for the study of monoclonality in lymphoid tumors, immunodeficiency associated or idiopathic lymphoproliferative syndromes, and myelomas in research use.Histosonda? Immunoglob
1.MoghimiM, KashkooliBehrooziM,MaghbooliM,etal.Assoaition between abnormal serum free light chain sratioand known prognostic factorsin lyphoma;anephrologyview point[J].JRenal InjPrev,2016. 2.Jardin F, Delfau-Larue MH, Molina TJ,etal. Immunoglobulin heavy chain/ light chain pairmeasurement is ...
Immunofixation electrophoresis did not show a typical paraprotein band but did show, in the gamma region, two large diffuse bands and a lower concentration of oligoclonal-type bands, all of which stained for free lambda but not for free kappa chain. The ratio of kappa to lambda chains in ...
(P= 0.3), type of myeloma wither IgG or IgA (P= 0.7), and wither were recently diagnosed or already on treatment (P=0.7).TF levels were significantly higher in patients expressing Lambda compared with those expressing Kappa chain(... HMZ Elabedin,EA Hassan,MAE Amir,... 被引量: 0发表...
kappa/lambdaratioimmunoglobulinsparaproteinmultiplemyelomamacroglobulinemialightchaindiseaseThis study compared the quantitation of immunoglobulins and light chains with qualitative analysis by immunoelectrophoresis and immunofixation to determine the usefulness of these techniques for the detection of monoclonal ...
Normalization of free light chain kappa/lambda ratio is a robust prognostic indicator of favorable outcome in patients with multiple myeloma PurposeTo clarify the impact of serum free light chain (sFLC) ratio normalization in patients with multiple myeloma (MM) treated with novel agents.Patients......