Quantitation of free kappa light chains in serum and urine using a monoclonal antibody based inhibition enzyme-linked immunoassay. J Immunol Methods. 1987;99:141-147.Axiak SM et al. " Quantitation of free kappa light chains in serum and urine using a monoclonal antibody based inhibition enzyme-...
Immunoglobulins belong to a group of related glyco proteins which make up 20% of serum proteins. Antigens and immunoglobulins react to confer immunity to individuals. Immunoglobulins have similar structures of two identical heavy chains and two identical light chains. Both the heavy chains and the ...
Serum kappa free light chain (FLC) was extremely elevated, >33,000 mg/dL. Treatment with therapeutic plasma exchange (TPE) started day 2 for biopsy-confirmed cast nephropathy. Bortezomib-containing chemotherapy was initiated on day 5, and hemodialysis for tumor lysis syndrome on day 7. TPE ...
Introduction Kappa and lambda free light chains (FLC) are a side product of immunoglobulin synthesis. They are small molecular weight proteins and are present in serum of healthy people. They are increased in various diseases with enhanced immunoglobulin production. Like other small molecular we...
Kappa free light chains (KFLC) index has been described as a reliable marker of intrathecal immunoglobulin G (IgG) synthesis in multiple sclerosis (MS), resulting even more accurate than IgG index to discriminate MS from other neurological diseases1,2,3. Immunoglobulin free light chains (FLC),...
The paper deals with examination of free kappa light chains (FKLC) in the cerebrospinal fluid and serum of patients with multiple sclerosis (MS). The patient group included 84 women (mean age 34.03 ± 10.33 years) and 24 men (mean age 33.81 ± 10.61 years). The average disease duration ...
Free Light Chains (FLCs) are immunoglobulin light chains which are circulating in serum in a free state (unbound). There are two types of immunoglobulin light chain produced in humans, designated kappa (κ) and lambda (λ). The quantification of serum FLC is used as an aid in the diagnosi...
Purified IgG was prepared from whole serum by affinity chromatography on kappa light chains linked to agarose. Buffer Solution Phosphate buffered saline Preservative Stabilisers <0.1% Sodium Azide (NaN3) Immunogen Mouse paraproteins with kappa light chains. Approx. Protein Concentrations Ig concentration ...
Meanwhile, serum total kappa and lambda are routinely measured in the majority of Chinese hospitals, which give serum total K/L a broader application field as a population screening indicator. Changes in free light chains may affect the ratio of total serum light chains. The serum free light ...
Katzmann JA, Clark RJ, Abraham RS, Bryant S, Lymp JF, Bradwell AR, Kyle RA (2002) Serum reference intervals and diagnostic ranges for free kappa and free lambda immunoglobulin light chains: relative sensitivity for detection of monoclonal light chains. Clin Chem 48:1437–1444 CAS PubMed Googl...