Numerous studies have demonstrated elevated kappa free light chains (KFLCs) in CSF of multiple sclerosis (MS) patients. However, so far only small cohorts have been examined, and generally only through qualitative KFLCs analysis. Using a recently developed free light chain (FLC) immunoassay, it ...
Elevated CSF free kappa light chains (FKLCs) may predict disability in multiple sclerosis (MS). We reviewed records of 57 patients with MS with 15-year median follow-up for correlations of disability and CSF FKLCs. Levels > or = 1.53 microg/mL predicted progression to need for ambulatory ...
Patients with IDDM diagnosed within two months, presented with normal albumin excretion, whereas the concentrations of 尾 2 -microglobulin and kappa light chain in urine were higher than in control subjects. The initiation of insulin therapy reduced, but did not completely normalize, the elevated ...
Rinker, J. R. 2nd., Trinkaus, K. & Cross, A. H. Elevated CSF free kappa light chains correlate with disability prognosis in multiple sclerosis.Neurology67, 1288–1290 (2006). ArticleCASGoogle Scholar Voortman, M. M.et al.Prognostic value of free light chains lambda and kappa in early m...
It was significantly elevated in CIS with presence of OCB (p<0.001). Q KFLC significantly correlated with other CSF variables such as CSF leukocyte count (p<0.001, R = 0.46), CSF CXCL13 levels (p<0.001, R = 0.64) and also intrathecal IgG synthesis (p<0.001, R = 0.74) as determined...
Serum FLC levels increase when FLC production is elevated, presumably as a result of B-cell activation in inflammatory diseases [99,106,107], such as autoimmune diseases [87,90,96] and infections [93,108,109]. Intrathecal Ig light chain synthesis is commonly observed in inflammatory disorders,...
The healthy negative group included patients with a healthy physical examination and non-elevated kappa and lambda levels. All the samples were divided into two groups, the samples from January 2021 to September 2022 were used as a modeling group for obtaining optimal cutoff values, and the ...
Isotype Control0109-05 SpecificityReacts with human κ light chains SourcePooled antisera from goats hyperimmunized with human κ light chains Cross AdsorptionHuman λ light chains; may react with κ light chains from other species Purification MethodAffinity chromatography on human κ light chains cova...
Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is a crucial transcription factor that participates in a number of physiological and pathological conditions, including immune response, apoptosis, carcinogenesis and inflammatory processes. It is involved in the rapid response to ...
Light chain immunohistochemistry is also complicated by an elevated background due to non-specific uptake of immunoglobulin by a variety of cells or staining of extracellular serum or stromal immunoglobulin molecules.Immunoglobulin light chainantibodies must always be interpreted as a pair, with the ...