Comparison of serum and urine kappa/lambda ratios as a kappa/lambda index may help reduce the need for more complex immunoelectrophoresis techniques in identifying free light chains in urine. 展开 关键词: IMMUNOFIXATION ELECTROPHORESIS LIGHTCHAIN DEPOSITION DISEASE SENSITIVITY URINE ...
Kappa chainsLambda chainsImmunoelectrophoresisNephelometryUrineBence Jones proteinsThe most sensitive routine method for identifying urinary monoclonal immunoglobulin kappa and lambda light chains, called Bence Jones proteins (BJPs), in clinical laboratories is immunofixation electrophoresis (IFE), but this ...
Sixty-eight previously untreated patients with IgG myeloma who were entered into five protocols of Cancer and Leukemia Group B (CALGB) were studied in order to determine the possible influence of excretion of kappa versus lambda urinary light chains on responses to treatment and survival. All patien...
N Latex Free Light Chain (FLC) kappa and lambda assays enable more-reliable management of patients with monoclonal gammopathies. Designed for use on nephelometric Atellica® NEPH 630* and BN™ Systems, these high-sensitivity assays provide: Concordance with IMWG recommendations and other internatio...
The variability subgroup of human monoclonal kappa chains purified from urine in 3 consecutive patients with myeloma associated light chain deposition disease was determined from amino acid sequences of their first framework regions (FR1). N-glycosylation was searched for by N-glycosidase F treatment....
Katzmann JA, Clark RJ, Abraham RS, Bryant S, Lymp JF, Bradwell AR, Kyle RA (2002) Serum reference intervals and diagnostic ranges for free kappa and free lambda immunoglobulin light chains: relative sensitivity for detection of monoclonal light chains. Clin Chem 48:1437–1444 CAS PubMed Googl...
Automated Immunoassay for Immunoglobulin Free Light Chains in Serum and Urine. Clin C28h.emMe2s0s0in1g:e4r7(M4).:T6h7o3m-8a0s. L. Immunfixations-Elektrophorese (Irb) zum Screening auf Bence Jones-Proteinurie. Lab med 1992; 16: 262-6. 29. Levinson SS, Keren DF. Free Light Chains ...
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Article Immunonephelometrische Bestimmung der Leichtketten von Immunglobulinen und des Kappa/Lambda-Quotienten im Urin bei Patienten mit monoklonaler Gammopathie. Immunonephelometrical Analysis of Immunoglobulin Light Chains and Kappa/Lambda Ratio in Uri
Free kappa and lambda light chains in fat tissue supernatants were quantified with a nephelometric immunoassay (FreeLite~(TM)) with specific antibodies against hidden epitopes (1). The 95% confidence limits of controls were calculated for kappa, lambda, and the ratio of both light chains. Congo...