目的评价脊髓血清和糖皮质激素诱导激酶1(SGK-1)/Kalirin-7/含2B亚基的N-甲基-D-天冬氨酸受体(NR2B)在大鼠2型糖尿病神经病理性痛(DNP)中的作用。 方法清洁级雄性SD大鼠72只,6周龄,体质量120～160 g,随机接受正常饲料喂养[正常对照组(C组, n=12)]和高脂高糖喂养( n=60)。采用高脂高糖喂养8周后腹腔注射...
AMPA受体的GluR2/3亚基,kalirin-7,NMDA受体的NRl和NR2B亚基表达以及AMPA和NMDA受体磷酸化均与CUMS/SAL组相同; 3,注射8-OH-DPAT能明显改善应激引起的抑郁样行为表现,并使海马5-HTlAR,AMPA受体的GluR2/3亚基,kalirn-7表达显著增加,NMDA受体的NR1和NR2B亚基表达显著降低,AMPA受体磷酸化显著升高,NMDA受体磷酸化显著...
XBP1s transcriptionally activated Kalirin-7 (Kal7), a protein that controls synaptic plasticity. In addition, we found reduced levels of Kal7 in primary neurons exposed to Aβ oligomers, transgenic mouse models and human AD brains. Short hairpin RNA-mediated knockdown of Kal7 altered synaptic ...
A Novel Synthetic Derivative of Phloroglucinol Inhibits Neuroinflammatory Responses Through Attenuating Kalirin Signaling Pathway in Murine BV2 Microglial Cells... - 《Molecular Neurobiology》 被引量: 0发表: 2018年 加载更多来源期刊 Molecular Neurobiology 站内活动 ...
《Kalirin 7 在雌激素调节海马神经元可塑性中的作用》是依托陕西师范大学，由马新明担任项目负责人的面上项目。项目摘要 神经树突棘是长期的信息处理和贮存记忆的物质基础。雌激素（E2）调节海马神经元树突棘和兴奋性突触的形成，但是基本机制尚未了解。Kalirin７ (Kal7)在海马神经元兴奋性突触的突触后独特地表达。海马...