We proposed a phase 2, open, prospective, multicenter, nonrandomized clinical trial for the adoptive infusion of haploidentical K562-mb15-41BBLeactivated and expanded natural killer (NKAE) cells as a consolidation strategy for children with favorable and intermediate risk acute myeloid leukemia in ...
另一种流行的nk细胞疗法是使用饲养细胞扩增nk细胞,如k562细胞修饰的膜结合分子,例如白介素(il)-15和4-1bb配体(k562-mb15-41bbl)。这些饲养细胞可以迅速地从外周血单个核细胞扩增nk细胞,使nk细胞在第7天平均扩增21.6倍,第21天扩增277倍。但是,由于衰老导致的端粒酶缩短,所以会限制继续扩增。 获得大剂量nk细胞通常...
另一种流行的NK细胞疗法是使用饲养细胞扩增NK细胞,如K562细胞修饰的膜结合分子,例如白介素(IL)-15和4-1BB配体(K562-mb15-41BBL)。这些饲养细胞可以迅速地从外周血单个核细胞扩增NK细胞,使NK细胞在第7天平均扩增21.6倍,第21天扩增277倍。但是,由于衰老导致的端粒酶缩短,所以会限制继续扩增。 获得大剂量NK细胞...
另一种流行的NK细胞疗法是使 用饲养细胞扩增NK细胞,如K562细胞修饰的膜结合分子,例如白介素(IL)-15和4-1BB配体 (K562-mb15-41BBL)。这些饲养细胞可以迅速地从外周血单个核细胞扩增NK细胞,使NK细胞 在第7天平均扩增21.6倍,第21天扩增277倍。但是,由于衰老导致的端粒酶缩短,所以会限 制继续扩增。 [0005] ...
We proposed a phase II open, a prospective multicenter, non-randomized clinical trial for adoptive infusion of haploidentical K562-mb15-41BBL activated and expanded Natural Killer (NKAE) cells as a consolidation strategy in children with favorable and intermediate-risk AML who were in first ...
International Journal of Molecular Sciences Article Recurrent Stimulation of Natural Killer Cell Clones with K562 Expressing Membrane-Bound Interleukin-21 Affects Their Phenotype, Interferon-γ Production, and Lifespan Maria A. Streltsova 1, Sofya A. Erokhina 1, Leonid M. Kanevskiy 1, Maria V. ...