We found that neither compromised the in vitro anti-tumour activity of NKG2D CAR-T cells. Interestingly, the expression of T cell exhaustion markers, TIGIT, TIM3 and LAG3, was reduced with extended manufacturing. To enhance the safety profile of the NKG2D CAR-T cells, we incorporated a full...
Expanded Vγ9Vδ2 T cells displayed an effector memory phenotype with a concomitant down-regulated expression of inhibitory immune checkpoint receptors. Finally, we ascertained the cytotoxic activity of these expanded cells by using nonmodified and chimeric antigen receptor (CAR)–engrafted Vγ9Vδ2 ...
CARMAI基因沉默的细胞株。K562/shCARMA1-93对CARMA1的抑制效果最好,利用该模型进行后续研究。台盼蓝拒染法和 克隆形成实验表明,l<562/shcARMA1-93的生长和克隆形成能力受到明显抑制(P<0.01)。与空白对照K562和阴性对照 K562/sh-eGFP相比,细胞生长抑制率分别为29.3%和28.6%;克隆形成抑制率分别为37.6%和34.1%。
An unpaired t-test was applied to the results with significant differences (*; p<0.05, **; p<0.01, ***; p<0.0001) from vehicle alone. The intracellular concentrations of PP IX and heme were measured at various times after the addition of 5 μM of PP IX (Fig. 1B, S1C and D)....
Asano T., Nakamura K., Fujii H., Horichi N., Ohmori T., Hasegawa K., Isoe T., Adachi M., Otake N.,Fukunaga Y.: Altered expression of topoiso- merase IIα contributes to cross-resistant to etoposide K562/MX2 cell line by aberrant methylation. Br. J. Cancer, 2005; 92: 1486-...
Kinetics of internalization and cytotoxicity of Trf-neocarzinostatin conjugate in human leukemia cell line, K562. J Cancer Res Jpn 1990; 81:91–99.Kohgo, Y., Kondo, H., Kato, J., Sasaki, K., Tsushima, N., Nishi- sato, T., Hirayama, M., Fuj...
Atasever B, Ülküseven B, Bal-Demirci T, Erdem-Kuruca S, Solakoğlu Z. Cytotoxic activities of new iron(III) and nickel(II) chelates of some S-methyl-thiosemicarbazones on K562 and ECV304 cells. Invest New Drugs. 2010;28:421–32....
(2011). Inhibition of K562 leukemia angiogenesis and growth by selective Na+/H+ exchanger inhibitor cariporide through down-regulation of pro-angiogenesis factor VEGF. Leukemia Research, 11, 1506-1511.Gao W, Chang G, Wang J, Jin W, Wang L, Lin Y, Li H, Ma L, Li Q, Pang T: ...
(0s.i1g4n%al)lienqguamllyoluecpu- loers daonwdntrreagnuslcartiepdtiboyn IrBeTgKuladteoprlse.tFiounrtihnetrh,ethtwe oevdidifefenrceentocfeallsumlaarlcl onnutmexbtserinodficgaetneedst(h0a.1t 4th%e)IeBqtkuαallpyroutpe-inolrikdeolywmnroedguullaatteedd tbhye aIBctTivKitdyeopflaetfieown ...