NK cells were expanded ex vivo from haploidentical donor peripheral blood mononuclear cells in the presence of the locally generated feeder cell line K-562 with ectopic expression of 4-1BBL and mbIL-21. The median duration of expansion was 18days (interquartile range 15-19). The median ...
Keywords: NK cell clones; IL-2; K562-mbIL21; membrane-bound IL-21 1. Introduction The phenotype of natural killer cells (NK cells) substantially changes during their differentiation and activation, forming heterogeneous subpopulations with various expression of surface receptors, effector molecules, ...