Cisplatin is a prototype of platinum-based chemodrugs that can form platinum-DNA adducts to initiate apoptosis2,3. However, a major hurdle that prevents its long-term use is the drug resistance acquired by tumour cells4. Cisplatin resistance has been attributed to altered pharmacokinetic factors, ...
the balance between these two epigenetic enzymes is unknown. VRK1 regulates the level of H4K16 acetylation by activating Tip60. We have shown that the VRK1 and SIRT2 are able to form a stable protein complex. For this work, we used in vitro interaction, pull-down and in vitro kinase ass...
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