It contains several fea- tures that are characteristics of RNA-binding proteins, including two hnRNPK homology (KH) domains and an RGG amino acid motif (RGG box). FMR1 local- izes to both the nucleus and the cytoplasm and can also interact with two fragile X syndrome related factors, ...
The most widely spread motifs are the RNA recognition motif (RRM) and the K homology (KH) domain. In this article, we survey the complete Arabidopsis thaliana genome for proteins containing RRM and KH RNA-binding domains. The Arabidopsis genome encodes 196 RRM-containing proteins, a more ...
It comprises three K-homology (KH) RNA binding domains with a clear preference for C-rich sequences [3], in addition to a less characterized K interactive region (KI) that is thought to allow interaction with multiple other proteins [1]. HNRNPK plays crucial roles in several biological ...
AlphaFold indicated that KH1 (purple) and KH3 (pink) domains are spatially closed and that there is space between them that could accommodate RNAs (Supplementary Fig.4e). We also found that hnRNPK depletion led to the cytoplasmic accumulation ofKCTD133XTs in HeLa cells (Supplementary Fig.4f)....
(Fig.4D and Additional file5A) and RIP analysis (Fig.4E). In addition, we confirmed the colocalization of endogenously expressed LINC00571, HNRNPK, and ILF2 in the nucleus by immunofluorescence in situ hybridization analysis (Fig.4F). HNRNPK contains three K-homology (KH) domains that ...
Besides the helicase core domain located in its C terminus, DDX43 also possesses potential K-homology (KH) domains at its N terminus (supplemental Fig. S1B) with its hallmark sequence, GXXG (19). The KH domain was first identified in the human heterogeneous nuclear ribonucleoprotein K (hnRNP...
Furthermore, we found all three KH (hnRNP K homology) domains of hnRNP K could unfold the c-MYC i-motif structure, and KH2 and KH3 were more active than KH1. In conclusion, this study may deepen our understanding of the interactions between i-motifs and PCBPs and may be helpful for ...
20 It contains three repeats of K homology (KH) domains (KH1, KH2, and KH3), one K-protein-interactive (KI) domain, and one nuclear-cytoplasmic shuttling domain (KNS). As an RNA-recognition motif, KH domains are responsible for recognizing target mRNAs.21 The nuclear-localization signal ...
The protein encoded by this gene is located in the nucleoplasm and has three repeats of KH domains that binds to RNAs. It is distinct among other hnRNP proteins in its binding preference; it binds tenaciously to poly(C). This protein is also thought to have a role during cell cycle ...
One important and widely distributed class of RNA-binding proteins contains K homology (KH)1 domains (2). This class of proteins includes such biologically significant KH domain-containing proteins as the FMR protein, which is involved in Fragile X mental retardation (3), the Drosophila bicaudal ...