Structural homology models of NTRK1 in DFG-in (type I) or DFG-out (type II) conformations bound to larotrectinib (g) or altiratinib (h); type I and type II are the favored binding modes for larotrectinib and altiratinib, respectively. Full size image Table 1 Dissociation constants ...
该KHDRBS1 Polyclonal Antibody. This gene encodes a member of the K homology domain-containing, RNA-binding, signal transduction-associated protein family. The encoded protein appears to have many functions and may be involved in a variety of cellular processes, including alternative splicing, cell ...
Arabidopsis thaliana FLOWERING LOCUS WITH KH DOMAINS (FLK) and PEPPER (PEP) genes encode RNA-binding proteins that contain three K-homology (KH)-domain, the typical configuration of Poly(C)-binding ribonucleoproteins (PCBPs). We previously demonstrated that FLK and PEP interact to regulate ...
Cohen Y, Shalmon B, Korach J, Barshack I, Fridman E, Rechavi G (2010) AKT1 pleckstrin homology domain E17K activating mutation in endometrial carcinoma. Gynecol Oncol 116: 88–91. Davies R, Gant TW, Smith LL, Styles JA (1999) Tamoxifen induces G:C–4T:A mutations in the cII gene ...
(PKB gamma ). All three Akts contain an amino-terminal pleckstrin homology domain, a central kinase domain, and a carboxyl-terminal regulatory domain. Akt1 is the most widely expressed family member and is frequently activated in a number of carcinomas, including breast, prostate, lung, ...
Gene set enrichment analysis GLS: Glutaminase GLUD: Glutamate dehydrogenase α-KG: α-ketoglutarate KH: k-homology CHX: Cycloheximide OS: Overall survival RFS: Recurrence free survival DMFS: Distant metastasis-free survival References Article Article PubMed Central...
1. Introduction and results 2. Triangulations of 4-manifolds 3. Group actions on 16 points, and equivariant triangulations 4. The 16-vertex triangulation K and its vertex link 5. Homology, tightness, and the Kummer configuration 6. The intersection form of K References Cited by (18) Figures ...
Bromo-adjacent homology-plant homeodomain domain containing protein 1 (BP1) is a reader of histone post-translational modifications in fungi. BP1 recognizes trimethylation of lysine 27 in histone H3 (H3K27me3), an epigenetic hallmark of gene silencing. H
We thus modeled these from FASTA sequences using SWISS-MODEL (http://swissmodel.expasy.org) [28] homology modeling starting from TRKA 7VKO as a template. To examine the influence of secondary mutations on the zurletrectinib-TRK interaction, we generated several solvent-front and xDFG mutant...
HR is largely error free which needs extensive homology for repairing DNA DSBs [207]. K63-linked ubiquitination of RYBP keep it away from DNA damage sites, which impairs BRCA1 recruitment and Rad51 to DNA double-strand breaks, thus suppressing HR repair. As a result, cancer cells with high...