④随着ZBTB7BmRNA的表达的下降,Jurkat细胞表面分子CD4/CD8的表达无显著改变,证明Jurkat细胞中CD4/CD8的表达与ZBTB7B的表达不相关。关键词:锌指结构转录调节因子(ZBTB7B);P14ARF;重组腺病毒;转染重庆医科大学硕士研究生学位论文EFFECTOFSIRNATARGETINGZBTB7BONTHEEXPRESSIONOFCD4/CD8ANDP14AI江INJURKATCELLSABSTRACTObjective:...
Detection of GABA-A channel subunit proteins in CD4+ and CD8+ T cells from rats, mice and the Jurkat cell line.Suresh, K. MenduAmol, BhandageZhe, JinBryndis, Birnir
在人类肿瘤和老鼠模型中,Tal1高表达与胸腺细胞CD4+CD8+阶段分化阻滞相关,而Jurkat细胞是CD4+CD8+T-ALL细胞,而且TAL1 异常表达,在多种T-ALL分子研究中被应用[2, 5],所以在我们的研究中应用了Jurkat 细胞作为研究对象。Jurkat 细胞属于WT型Tal1高表达的细胞株,为了更确切的说明Tal1对T-ALL细胞增殖的影响,下一...
Jurkat 细胞免疫表型:CD2+、CD3+、CD4+、CD6+、CD7+、CD8-、CD19-、CD34+、TCRα/β+、 TCRγ/δ-。Jurkat 细胞是亚四倍体,细胞遗传学特点:87(78-91) 4nXX, -Y, -Y, -5, -16, -17, -22, (2)(p21)/del(2)(p23)x2, der(5)t(5;10)(q11;p15), del(9)(p11)。针对上述免疫学和...
人T淋巴细胞系Jurkat细胞最初来源于一名14岁T-ALL初次复发的男性患者。Jurkat 细胞免疫表型:CD2+、CD3+、CD4+、CD6+、CD7+、CD8-、CD19-、CD34+、TCRα/β+、 TCRγ/δ-。Jurkat细胞是亚四倍体,细胞遗传学特点:87(7 君,已阅读到文档的结尾了呢~~ ...
The response of the human CD4+ T-cell line Jurkat to infection with vaccinia virus was investigated. Virus titers peaked approximately 3 to 4 days after infection, while cell growth paralleled that of uninfected cells, indicating that growth rates were not appreciably affected by viral infection....
Inducible Co-stimulator (ICOS, CD278)is an immunostimulatory IC and a member of the CD28 superfamily. Expression of ICOS is rapidly induced in CD4 and CD8 T cells upon their activation, whereas its ligand ICOS-L (CD275), is mostly expressed by APCs [1]. ...
Nearly all human CD4+ T cells and 50% of human CD8+ T cells express CD28. The CD28 interaction with CD80 (aka B7-1) or CD86 (aka B7-2) on APCs, in conjunction with TCR engagement, triggers a co-stimulation signal (signal 2). It results in T cell proliferation, cytokine production...
In activated CD4+ T cells, the Vav1-Rac pathway is a critical component of TCR-induced cell death[21]. However, Vav1 has also been reported to be a pro-survival molecule in different signaling contexts. For instance, overexpression of Vav1 counteracts CD4-mediated apoptosis of T cells by ...
CD28 is a homodimeric and transmembrane protein expressed by T cells. Nearly all human CD4+ T cells and 50% of human CD8+ T cells express CD28. The CD28 interaction with CD80 (aka B7-1) or CD86 (aka B7-2) on APCs, in conjunction with TCR engagement, triggers a co-stimulation sign...