jun-fosprotein designDimerization of the JunFos activator protein-1 (AP-1) transcriptional regulator is mediated by coiled coil regions that facilitate binding of the basic regions to a specific promoter. AP-1 i
The term “Fos/Jun” is used for a number of structurally and functionally related members of the Fos and Jun protein families of transcription factors, collectively described as activating protein-1 (AP-1). AP-1 mediates gene regulation in response to cytokines, growth factors and stress signal...
网络释义 1. 异源二聚体 但当Fos 与Jun 通过LZ 途径形成异源二聚体(Jun-Fos)的核蛋白复合物后,即能以高亲和力结合在靶基因的DNA 相关序列即AP-1… lunwendr.com|基于 1 个网页
有亮氨酸拉链模式的Jun和Fos蛋白是以二聚体或四聚体的形式结合DNA的。( )答案:消失|重建|类型|代谢状态解析:核仁是真核细胞核内高度动态的结构,其大小、形状和数
产品名称:Jun/Fos EZ-TFA Chemiluminescent .0订购此产品 供应商:Millipore 规格:EA 目录价:7579 库存状态: CAS编号: 应用范围: 种属来源: 相关信息: 保存条件: 说明书地址:点击查看详细 打印此页关闭此页 上一个:c-Fos EZ-TFA Chemiluminescent[70-645/EA] ...
(1988) The c-fos protein interacts with c-jun/AP-1 to stimulate transcription of AP-1-responsive genes.Cell 54, 541–552. PubMed CAS Google Scholar Cho K., Skarnes W., Minsk B., Palmieri S., Jackson-Grunsby L., and Wagner J. (1989) Nerve growth factor regulates gene expression...
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关键词Jtm;Fos;AP-I;肿瘤 人类e-jun是禽肉瘤逆转录病毒基因ASV17的 细胞内同源基因,由Bol’unann等人于1987年发 现uJ.人类c—f0s基因是鼠FBJ一骨肉瘤逆转录病毒 基因v-f0s的细胞内同源基因,1983年由,ranStraaten 成功克隆J.细胞内c.Jun借助于其碱性亮氨酸拉 ...
(et-1)基因ap-1位点与核蛋白结合的影响及肿瘤促进剂佛波酯(tpa)对c-fos/c-jun基因表达的作用.结果发现,c-jun抗体可使ap-1位点-核蛋白复合物的电泳迁移率发生改变,tpa显著促进c-fos/c-jun基因表达和血管内皮细胞的ap-1结合活性.实验表明,tpa对et-1基因表达的诱导作用是通过促进ap-1转录因子c-fos/c-jun...
Using nonsumoylatable mutants of c-Fos and c-Jun as well as a chimeric protein mimicking sumoylated c-Fos, we show that sumoylation entails lower AP-1 transactivation activity. Interestingly, single sumoylation at any of the three acceptor sites of the c-Fos/c-Jun dimer is sufficient...