Dominant-negative mutant of c-Jun gene transfer: a novel therapeutic strategy for colorectal cancer. Activator protein-1 (AP-1), a transcription factor, is activated through many oncogenic signals. However, its biological role in colorectal cancer has not ... Suto,R.,Tominaga,... - 《Gene ...
Enhancer dysregulation is one of the important features for cancer cells. Enhancers enriched with H3K4me3 have been implicated to play important roles in cancer. However, their detailed features and regulatory mechanisms have not been well characterized.#Here, we profile the landscape of H3K4me3-enriche...
Sa1706 MicroRNA-139-5p Exerts Tumor Suppressor Function by Targeting Notch1 and Jun in Colorectal Cancer - Gastroenterologydoi:10.1016/S0016-5085(13)61019-7Zhang, LijingDong, Yu JuanZhu, NanaWu, Chung-WahZhao, JunhongSung, Joseph J.Y.
In their Nature paper, Axel Behrens and colleagues now show that c-JUN is part of a transcriptional complex that is central to the development of colorectal cancer.doi:10.1038/nrc1687McCarthyNicolaNature Reviews Cancer
the enhancer heptamer motif 5'-TGA[CG]TCA-3'. It promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) ...
the enhancer heptamer motif 5'-TGA[CG]TCA-3'. It promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) ...
In order to characterize the induction by activator protein 1 in colorectal cancer by glutathione S-transferase alpha 4, Santa Cruz Biotechnology c-Jun antibody (Santa Cruz, sc-822) was used in immunocytochemistry on mouse samples at 1:400 (fig 5). Oncogene (2016) ncbi mouse monoclonal (KM-...
the enhancer heptamer motif 5'-TGA[CG]TCA-3'. It promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) ...
[7] Juneja M,Ilm K,Schlag PM,Stein U.Promoter identification and transcriptional regulation of the metastasis gene MACC1 in colorectal cancer[J].Mol Oncol,2013,7(5):929-943. [8] 朱皓皞,于晓红,杜丽英,等.宫颈癌中激活蛋白1通路的活化及临床意义[J].东南国防医药,2014,16(2):128-131. ...
Expression of glutaminase is upregulated in colorectal cancer and of clinical significance. Int. J. Clin. Exp. Pathol. 7, 1093–1100 (2014). PubMed PubMed Central Google Scholar Pan, T. et al. Elevated expression of glutaminase confers glucose utilization via glutaminolysis in prostate cancer...