Hao Z, Xing Z, Tan J, Zhao Y, Li M. Impinging Flow Induces Expression of Monocyte Chemoattractant Protein-1 in Endothelial Cells Through Activation of the c-Jun N-terminal Kinase/c-Jun/p38/c-Fos Pathway [publi...
is also a key player in regulating inflammatory processes.1 AP-1 is composed of homodimeric and heterodimeric complexes consisting of members of the Jun, Fos, activating transcription factor and musculoaponeurotic fibrosarcoma protein families.2 It can be activated by growth factors, cytokines, chemok...
有亮氨酸拉链模式的Jun和Fos蛋白是以二聚体或四聚体的形式结合DNA的。( ) 2判断题(15分,每题5分)1. 有亮氨酸拉链模式的Jun和Fos蛋白是以二聚体或四聚体的形式结合DNA的。( ) 3有亮氨酸拉链模式的 Jun 和 Fos 蛋白是以二聚体或四聚体的形式 结合DNA的。( ) 4判断题(45分,每题5分)1. 有...
Definition The term “Fos/Jun” is used for a number of structurally and functionally related members of the Fos and Jun protein families of transcription factors, collectively described as activating protein-1 (AP-1). AP-1 mediates gene regulation in response to cytokines, growth factors and st...
The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. Biochim Biophys acta. 1991;1072(2–3):129–57. CAS PubMed Google Scholar Hartl M, Bader AG, Bister K. Molecular targets of the oncogenic transcription factor jun. Curr Cancer Drug Targets. 2003 Feb;3(...
ZEB1 in TGFβ-treated NOS2KO cells (Supp. Fig.5G, H). These findings enabled us to focus on the transcriptional machinery regulating the expression ofTGFB1andLCN2to identify direct targets of NOS in MpBC cells, including factors that act on AP-1 response elements like c-Jun and Fos30....
c-Jun是一种蛋白质,它形成同二聚体和异二聚体(带有例如c-Fos)以产生反式激活复合物AP,要求反式激活复合物AP活化与炎症反应有关的许多基因(例如基质金属蛋白酶)。当发现一些不同的刺激,如紫外(UV)光和TNF-α,刺激c-Jun在蛋白质N-末端特异性丝氨酸残基上发生磷酸化时,发现了JNKs。 三种不同JNK酶业已确定为...
IP-1 activity is blocked by stimulation of the protein kinase C (PKC) signal transduction pathway, achieved by treating HeLa cells with phorbol esters or with a diacylglycerol analog. We observed an increase in AP-1-DNA binding after treatment of the cells with either the calcium ionophore A-...
进一步的研究确定了LMP1 结构域CTAR2 可能通过结合TRADD/TRAF2 信号分子, 引起一系列 级联反应, 活化JNK, 从而激活AP-1 的两个重要组分 c-Jun 和 c-Fos[8]. 我们最近证实 EB 病毒 LMP1 通过 TRADD和TRAF激活JNK[9], 动态调控Jun B和c-Jun 表达及翻译后修饰1), 进行二聚体的重新组合, 形成 c-Jun/...
However, after screening the motifs of transcription factors that were significantly enriched using ATAC-seq data synchronously, we discovered that AP-1 and its relative transcription factors, such as JUN, FOS, and JUNB, were obviously enriched in CCRF-CEM(Dex) cells (Figure 2G). Together with ...