An epigenomic approach to therapy for tamoxifen-resistant breast cancer. Cell Res 2014; 24: 809–819. 20 Rajagopalan V, Vaidyanathan M, Janardhanam VA, Bradner JE. Pre-clinical analysis of changes in intra-cellular biochemistry of glioblastoma multiforme (GBM) cells due to c-Myc silencing. ...
cancer initiation, progression, metastasis, maintenance of cancer stem cells, and the acquisition of resistance to anti-cancer agents [[5], [6], [7]]. Some mechanisms responsible for the upregulation of SOX9 in cancer have been elucidated. For example, in esophageal cancer stem cell ...
As a BET inhibitor, JQ1 has been proved to exert anti-cancer effects against many hematological malignancies and solid tumors. Therefore, we investigated whether JQ1 had chemotherapeutic activities in GC cells. Based on expression levels, we chose AGS, HGC27, and MKN45 with high BRD4 expression ...
We learned previously that human breast cancer COH-BR1 cells underwent a rapid and robust phosphorylation–activation of the pro-survival/progression kinase Akt after an ALA/light challenge and that this subsided during prolonged post-irradiation incubation (23). Akt activation was nullified by wortman...
Fig. 1 Fatty acid metabolism in lung cancer Lung cancer cells obtain fatty acids from exogenous uptake and de novo lipogenesis. Exogenous uptake of fatty acids from the microenvironment is facilitated by CD36, FATP and FABP. De novo fatty ...
ESPARZA-LOPEZ J, ESCOBAR-ARRIAGA E, SOTO-GERMES S, et al. Breast cancer intra-tumor heterogeneity: one tumor, different entities[J]. Rev Invest Clin, 2017, 69(2): 66-76. SOUSA B, RIBEIRO A S, PAREDES J. Heterogeneity and plastic...
breast cancer cells was assessed using transwell migration and invasion experiments, and the migration and invasion abilities of mda-mb-231 and sk-br-3 cells were measured. additionally, it was evaluated whether cir...
肿瘤干细胞(cancer stem cell,CSC)是导致肿瘤治疗耐受、复发和转移的关键因素之一,然而CSC的清除仍较为困难。Liu等[56]发现EMSY通过蛋氨酸代谢影响组蛋白修饰,促进CSC的自我更新和肿瘤发生。研究提出,蛋氨酸剥夺饮食可以通过清除CSC抑制肿瘤进展,成为TNB...
Tang等[12]建立了含有神经前体细胞、星形胶质细胞、胶质母细胞瘤干细胞(glioblastoma stem cells,GSCs)和巨噬细胞的四重培养模型,发现与巨噬细胞共培养下的GSCs侵袭性增强且巨噬细胞多向M2极化,通过进行全基因组CRISPR-Cas9失功能筛选获得功能依赖性...
[25] LAWSON D A, BHAKTA N R, KESSENBROCK K, et al.Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells[J]. Nature, 2015, 526(7571): 131-135. [26]BRECHBUHL H M, VINOD-PAUL K, GILLEN...