Neuroinflammation plays a key role in the modulation of the pathogenesis of neurodegenerative disorders such as Alzheimer's disease (AD) and related tauopathies [1]-[3]. In AD, activated microglia may become neurotoxic through their increased expression of pro-inflammatory cytokines, which lead to ...
Molecular analysis for (de)myelination and neuroinflammation was applied to characterize the effect of cuprizone on CXCR3-deficient mice and control animals. Results CXCR3-deficient mice displayed a milder clinical course during cuprizone feeding and a more rapid body weight recovery after offset of ...
These differences may represent functionally important stages of innate immune activation and neuroinflammation along the AD continuum and are summarized in Additional file 3: Figure S2. Increasing inflammation with increasing neurodegeneration, but not Aβ pathology alone All of the inflammatory markers ...
Secondly, the function of VCAM1 is particularly relevant to neuroinflammation in stroke as it acts to permit extravasation of leukocytes through the vascular wall into brain tissue. Lastly, VCAM1 is well-reported in the literature in the context of ischemia, vascular comorbidities, and molecular ...
The discovery of a novel serum autoantibody (termed NMO-IgG or AQP4-Ab) in a subset of patients in 2004 has revived interest in neuromyelitis optica (NMO). While the history of classical multiple sclerosis has been extensively studied, only little is kno
an individual biomarker with expression correlating to progression was not identified. Instead, more advanced disease stages involved additional pathways. Hence, our results identify PINK1 deficiency as an early modulator of innate immunity in neurons, which precedes late stages of neuroinflammation during ...
Repeated E-52862 promotes gradual normalization of mechanical sensitivity inhibiting neuroinflammation, critical for osteoarthritic pain. E-52862 antinociception involves μ-opioid receptors and reverses morphine tolerance during chronic osteoarthritic pain. What is the clinical significance E-52862 could dampen...
The discovery of a novel serum autoantibody (termed NMO-IgG or AQP4-Ab) in a subset of patients in 2004 has revived interest in neuromyelitis optica (NMO). While the history of classical multiple sclerosis has been extensively studied, only little is kno
an individual biomarker with expression correlating to progression was not identified. Instead, more advanced disease stages involved additional pathways. Hence, our results identify PINK1 deficiency as an early modulator of innate immunity in neurons, which precedes late stages of neuroinflammation during ...
Names of peptides are constructed using “gene name abbreviation + the first three N-terminal amino acids of the peptide.” The peptides were purchased from Cambridge Research Biochemicals and exhibit purity > 95% (via reversed-phase (RP) LC and mass determined by matrix-assisted laser ...