Our understanding of cancer biology has increased substantially over the past 30 years. Despite this, and an increasing pharmaceutical company expenditure on research and development, the approval of novel oncology drugs during the past decade continues to be modest. In addition, the attrition of agen...
Publications cover a broad range of topics of general interest but should be within relevant fields of biology, including: • aging, cancer biology, molecular medicine, stem cells and regenerative medicine • autophagy, cell biology, organelle biology, membrane and intracellular transport • ...
select article Small Molecules Detected by Second-Harmonic Generation Modulate the Conformation of Monomeric α-Synuclein and Reduce Its Aggregation in Cells Research articleOpen access Small Molecules Detected by Second-Harmonic Generation Modulate the Conformation of Monomeric α-Synuclein and Reduce Its Ag...
The development of therapies specifically targeting the molecules responsible for the transformed phenotype demands a detailed understanding of the mechanisms behind normal cellular processes. This knowledge should not be gained at the expense of an appreciation of the impact that bench-based research has...
REINVENT 4 is a modern open-source generative AI framework for the design of small molecules. The software utilizes recurrent neural networks and transformer architectures to drive molecule generation. These generators are seamlessly embedded within the general machine learning optimization algorithms, transf...
影响因子最高的一篇发表在老牌期刊《Hepatology》(IF= 14.079)上,更多的文章发表在PLOS BIOLOGY(IF=9.163)、eLife(IF=7.616)、International Journal of Cancer(IF= 7.360)、Environment international(IF= 7.297)、 The Plant Journal(IF= 5.775)、PLoS genetics(IF= 5.540)Journal of Experimental Botany (IF= 5.35...
INTERNATIONAL JOURNAL OF CANCER《国际癌症期刊》 国际标准刊号:ISSN0020-7136;EISSN1097-0215 核心类别:SCIE(2022版), 外文期刊, 投稿网址:http://mc.manuscriptcentral.com/ijc-wiley 期刊网址:https://onlinelibrary.wiley.com/journal/10970215 所属分区:2区 ...
[6]Calmus Y., Gane P., Rouger P., et al. Hepatic expression of class I and classII major histocompatibility complex molecules in primary biliary cirrhosis:effect of ursodeoxycholic acid[J]. Hepatology, Jan, 1990, 11 (1): 12-...
一下不觉又到中秋,影响因子也更新了一段时间。为此,小编为各位佬哥佬姐整理了322本 2024 年生信友好期刊,同时附上。数据来源截止今年7月份前,准不准确大家也可以看后评估,不过仅供参考。 (后台回复关键字可以查看相应期刊更多信息) 实时检索SCI收录状态:https://mjl.clarivate.com/home ...
Most chemotherapeutics elevate intracellular levels of reactive oxygen species (ROS), and many can alter redox-homeostasis of cancer cells. It is widely accepted that the anticancer effect of these chemotherapeutics is due to the induction of oxidative s