In conclusion, remibrutinib showed efficacy in preclinical models of MS and its mode of action extends beyond B cell inhibition to include direct anti-inflammatory effects on peripheral and central myeloid cells like microglia.Availability of data and materials Not applicable.References...
Country.South Korea had the most interventions (n = 5) [61,62,63,66,67], followed by Portugal (n = 3) [56,60,65]. Other countries, such as France [51,53], Greece [54,5564,70] and China [59,68], contributed two studies each. Canada [57], Germany [58] and Switzerl...
Molecular cloning was required in most cases to retrieve the18Ssequences because the variants differed in their lengths. Only the samples AH1895H (hSYAT02) and AH1982H (hCOLL3) were not cloned because their18Ssequences were fully readable following direct sequencing. Almost the complete18Ssequenc...
The smithing skills of craftsmen in the western Mediterranean during the early Iron Age can be determined by studying the microstructure of oxidised iron items. While some ghost structures have already been identified in dense corrosion products, their f
The paper is organized as follows. In Sect.2, we will review theand its relevant parameters for our analysis of neutrino, neutral Higgs and stop sectors. In Sect.3, we will introduce the phenomenology of the stop LSP, studying its pair production channels at the LHC and its signals. The...
We would like to thank Nicolas Ris (INRA Sophia-Antipolis, France), Jinping Zhang and Renya Liao (MoA-CABI Joint Laboratory for Biosafety, Beijing, China), Hao Wu, Guohua Chen, Yan Liu, Yan Xiong, Chun Xiao (Yunnan Agricultural University, Kunming, China) and Masahito T. Kimura (...
the Nernst equation applies. It is also important to remark that electrochemical measurements are an important source of thermodynamic and kinetic data. However, most electrochemical data (for instance, most standard electrode potentials) are not obtained from direct electrochemical measurements because of...
A question of great interest is whether the epidemic caused by SARS CoV-2 could have influenced the results of EDAD-2020. In this regard, while there seems to be agreement in the literature that COVID-19 was an element of risk for the mental health of caregivers [5, 15, 64, 72), ...
on the valley floor. The earliest phase of the site consist of 102 graves dated to the Middle Neolithic (4720–4350 cal BC), and include a dog’s burial. They belong to the Chambon culture according to the associated goods, especially the pottery, and provide direct dates from human bone...
and this pro-inflammatory effect was completely dependent on the presence of the spleen. These data demonstrate that the pro-inflammatory effect of an excess of ANGII on laser-induced CNV is strictly dependent on the presence of the spleen and not mediated by a direct effect of ANGII on vascul...