每一次的科研发现都凝聚着全体科研人员的心血，这种可能具有搅乱肿瘤代谢，让肿瘤的“瓦博格效应”瘫痪，...
JHU-083,CAS:1998725-11-3,JHU-083 (Ethyl 2-(2-Amino-4-methylpentanamido)-DON) is a novel prodrug of DON.JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells and prevents depression-associated behaviors induced by chronic social defeat str
厂商性质生产商 所属地区美洲 原产地上海-上海市 产品摘要 JHU-083 是 6-diazo-5-oxo-L-norleucine (DON; HY-108357) 的前药,是一种口服有效的,选择性的谷氨酰胺酶 (glutaminase) 拮抗剂,可阻断脑 CD11b+ 细胞和实验性脑疟疾 (ECM) 中的谷氨酰胺酶,导致动物中谷氨酸水平的净降低。
JHU-083, a prodrug of 6-diazo-5-oxo-L-norleucine (DON; HY-108357), is an orally active and selective glutaminase antagonist. JHU-083 blocks glutaminase activity in brain CD11b+ cells and experimental cerebral malaria (ECM) resulting in a net decrease of glutamate levels in the animals. Ch...
We thus tested JHU083, a novel, brain penetrant DON prodrug predicted to exhibit improved tolerability. Systemic administration of JHU083 reversed cognitive impairment in EcoHIV-infected mice similarly to DON, and simultaneously normalized EcoHIV-induced increases in cerebrospinal fluid (CSF) glutamate ...
Oral administration of JHU-038 led to the accumulation of micromolar concentrations of DON in the mouse brain. JHU-083 treatment significantly increased the survival of immune-competent animals bearing orthotopic tumors formed by the mouse cerebellar stem cell model as well as immune-deficient animals...