Key results: CB1R, which was induced in the liver sections of fibrotic patients and mice, promoted HSCs activation in liver fibrosis via recruiting β-arr1 and Akt signaling, while blockage of CB1R with JD5037 attenuated CB1R-regulated HSCs activation and liver fibrosis by repressing β-arr1/...
JMJD2A protein is a demethylase that is overexpressed in several tumors. Herein, our results demonstrate that JMJD2A accelerates malignant progression of liver cancer cells in vitro and in vivo. Mechanistically, JMJD2A promoted the expression and mature of pre-miR372 epigenetically. Notably, miR...
吕小俊目前担任益普号(上海)茶叶股份有限公司、云南易普号经贸有限公司等10家企业法定代表人,同时在6家企业担任高管,包括担任益普号(上海)茶叶股份有限公司董事兼总经理,云南易普号经贸有限公司执行董事兼总经理;二、吕小俊投资情况:吕小俊目前是4家企业直接控股股东,包括云南易普号茶叶有限公司、控股比例达84%,...
The peripheral CB1receptor antagonist JD5037 blocked this pathway, the activation of HSCs and liver fibrosis. This compound and the associated pathway may be a novel approach to the treatment of liver fibrosis. 展开 关键词: receptor receptors liver fibrosis ...
This study elucidates a novel mechanism for JMJD2A in liver cancer cells and suggests that JMJD2A can be used as a novel therapeutic targets of liver cancer. 展开 关键词: liver cancer HistoneH3 demethylase JMJD2A miR372 P21WAF1/Cip1 Pim1 ...
The peripheral CB1receptor antagonist JD5037 blocked this pathway, the activation of HSCs and liver fibrosis. This compound and the associated pathway may be a novel approach to the treatment of liver fibrosis.doi:10.1111/bph.15010Siwei Tan
The peripheral CB1R antagonist JD5037 blocks CB1R/β-arr1/Akt-regulated HSCs activation and liver fibrosis, and this compound and the associated network may be a novel potential therapeutic approach for treating liver fibrosis in the future.doi:10.1111/bph.15010...
Previous research highlighted the involvement of the cannabinoid CB1 receptor in regulating the physiology of hepatocytes and hepatic stellate cells. The inhibition of the CB1 receptor via peripherally restricted CB1 receptor inverse agonist JD5037 has s
ImadFromUthmanFromAbdul-GhaniFromKibbiFromSamerFromGhosnFromingentaconnectInternational Journal of DermatologyKurban M, Uthman I, Kibbi AG, Ghosn S. Acquired perforating dermatosis heralding metastatic renal cell carcinoma to the liver. Int J Dermatol 2008;47:1038-1040....
Conclusions: There is no significant difference in the liver and renal function between RIRS and Mini-PCNL in the treatment of upper ureteral calculi. RIRS can better improve the endocrine status of patients and reduce the damage of the body, which is a more ideal way of operation.Jin-Cheng ...