JC病毒(John Cunningham virus, JCV) 是一種人類多瘤病毒,為一種常見的環境病毒,大約39-58%的人群曾經被感染,抗JC病毒抗體檢測結果會呈現陽性反應。JC病毒感染後長期潛伏於腎臟等組織中,一般來說並不會對宿主造成任何影響,但若宿主的免疫系統有缺陷或被抑制,就可能造成JC病毒突變活化,進而穿過血腦屏障 (Blood bra...
We performed a cross-sectional study in 63 patients testing JCV-DNA in blood, peripheral blood cells and urine. We longitudinally assessed the presence of JCV-DNA in a cohort of 33 subjects, one of which developed PML. We could test retrospectively serum samples from another PML case occurred...
(1997). "Stereoselective passage of mefloquine through the blood-brain barrier in theAtwood WJ, Wang L, Durham LC, Amemiya K, Traub RG, Major EO: Evaluation of the role of cytokine activation in the multiplication of JC virus (JCV) in human fetal glial cells. J Neuro- virol 1995, 1:...