摘要: Anti-JC virus (JCV) antibody index is the predictive factor of progressive multifocal leukoencephalopathy (PML) for multiple sclerosis (MS) patients treating with natalizumab. The aim of this study...关键词: Multiple sclerosis JC virus Natalizumab Anti-JCV antibody positivity and index ...
Utility of Anti-JC Virus Antibody Index to Assess the Risk of PML in Natalizumab-Treated MS PatientsPerumal, Jai S.Neurology Alert
associatedwiththepresenceofanti–JCvirus(JCV)antibodies.Weanalyzedwhetheranti-JCVantibodylevels,meas- uredasindex,mayfurtherdefinePMLriskinseropositivepatients. Methods:Theassociationbetweenserumorplasmaanti-JCVantibodylevelsandPMLriskwasexaminedinanti-JCV ...
American Academy of Neurology. "Multiple sclerosis drug tied to rising JC virus antibody levels: Virus may induce deadly brain infection." ScienceDaily. ScienceDaily, 28 January 2016. <www.sciencedaily.com/releases/2016/01/160128074330.htm>....
Antibody indexJC virusKuwaitMultiple sclerosisRisk stratificationAnti-JC virus (JCV) antibody testing has been used increasingly to stratify multiple sclerosis (MS) patients into different disease modifying therapies.#We assessed JCV serostatus stability longitudinally in MS patients who were regularly ...
This conclusion was supported by another recent nested case-control study147 in which IgG antibody to JC virus was measured in 611 colorectal cancer cases, 123 adenomatous polyp cases, and matched controls. There was no association between antibodies to JCV and colorectal cancer, with OR 0.91 (...
The results of studies performed until now confirm the predictive value of anti-JCV antibody measurement in the assessment of PML risk; however, changes in serostatus need to be considered. 展开 关键词: multiple sclerosis JC virus anti‐JCV antibodies screening index ...
Human papovavirus JC (JCV) and simian virus 40 (SV40) genomes share approximately 69% homology; and there is antigenic cross-reactivity between JCV and SV40 tumor or T antigens. In order to determine whether a selective immune response to JCV T antigen could be demonstrated, transgenic mice ...
A significant correlation has been found between Epstein-Barr virus (EBV) and methylation of multiple genes in gastric cancer. However, little is known about the significance of JCvirus (JCV) T-antigen (T-Ag) expression in gastric cancers. In this study, the authors demonstrate that JCV T...
A monoclonal antibody to SV40 large T-antigen labels a nuclear antigen in JC virus-transformed cells and in progressive multifocal leukoencephalopathy (PML) brain infected with JC virus. J Neuroimmunol. 1988; 17 :331–345.Stoner, G. L., C. F. Ryschkewitsch, D. L. Walker, D. Soffer, ...