摘要: 沉默信息调节因子1(SIRT1)通过脱乙酰作用能抑制脂肪生成相关基因过氧化物酶体增殖物激活受体γ(PPARγ)和固醇调节元件结合蛋白1c(SREBP1c)的转录活性,从而抑制脂肪细胞分化,降低脂肪沉积,促进脂肪动员。SIRT1通过调节脂类代谢相关的信号通路SIRT1-腺苷酸活化蛋白激酶(AMPK)和SIRT1-哺乳动物雷帕霉素靶蛋白(mTOR...
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[ 26] FREYTAG S O,PAIELLI D L,GILBERT J D.Ectop⁃ ic expression of the CCAAT / enhancer⁃binding protein α promotes the adipogenic program in a variety of mouse fibroblastic cells [ J ] . Genes & Development, 1994,8(14) :1654-1663. [ 27] MOYNIHAN K A,IMAI S I. Sirt1 as...
Chinese Journal of Integrated Traditional and Western Medicine,2008,( 11) :1005-1009.( in Chinese) [ 60] FREYTAG S O,PAIELLI D L,GILBERT J D.Ectop⁃ ic expression of the CCAAT / enhancer⁃binding protein alpha promotes the adipogenic program in a variety of mouse fibroblastic cells [...