研究表明,升高的IFN-γ参与干眼的发病机制,并通过激活JAK2/STAT1信号通路促进角膜上皮焦亡。值得注意的是,本研究不仅在体内阐明了IFN-γ与细胞焦亡之间的联系,该结果也在体外得到了证实。 讲题: IFN-γ triggers corneal epithelial cell...
研究表明,升高的IFN-γ参与干眼的发病机制,并通过激活JAK2/STAT1信号通路促进角膜上皮焦亡。值得注意的是,本研究不仅在体内阐明了IFN-γ与细胞焦亡之间的联系,该结果也在体外得到了证实。 讲题: IFN-γ triggers corneal epithelial cell pyroptosis and NLRP3 inflammasome via JAK2/STAT1 pathway in dry eye diseas...
Overall, PRDX6 alleviated HF by inhibiting DOX-induced ferroptosis through the JAK2/STAT1 pathway inactivation.doi:10.1007/s11626-024-00889-0Xiong, JieZhou, RongDeng, XuSpringer USIn Vitro Cellular & Developmental Biology Animal
of high mobility group box-1 (HMGB1) on lipid deposition in interferon (IFN-γ)-stimulated mouse mesangial cell line (MMC) and to determine whether the Janus kinase 2 and signal transducer and activator of transcription 1 (JAK2/STAT1) signaling pathway plays an important role in this process....
Janus kinase 2/signal transducer and activators of transcription 1 (JAK2/STAT1) signaling is a common pathway that contributes to numerous inflammatory disorders, including different forms of acute lung injury (ALI). However, the role of JAK2/STAT1 in ve
在哺乳动物中,JAK家族有4个成员(JAK1、JAK2、JAK3、TYK2)和7个STATs(STAT1、STAT2、STAT3、STAT4、STAT5a、STAT5b、STAT6),形成复杂的下游信号通路。由于JAK-STAT通路在RA中发挥重要作用,阻断JAK或STAT激活可抑制炎症反应,延缓RA进展[5]。JAK-STAT...
signaling pathway,which may be involved in the pathogenesis of viral myocarditis then provide a cardioprotection.2.Overexpression of HO.1 downregulate gene expression of iNOS via JAK2/STATl signaling pathway in CVB3-induced myocarditis in mice. ...
SOCS2 Inhibits Mitochondrial Fatty Acid Oxidation via Suppressing LepR/JAK2/AMPK Signaling Pathway in Mouse Adipocytes. Oxid Med Cell Longev. 2020. [5] 郝雨知,蔡啸,金一峰等.基于JAK2/STAT1信号通路探讨骨桥蛋白缓解高血糖大鼠脑出血后炎症反应机制[J].卒中与神经疾病, 2021, 28(6):9. [6] 鲁慧东,...