研究表明,升高的IFN-γ参与干眼的发病机制,并通过激活JAK2/STAT1信号通路促进角膜上皮焦亡。值得注意的是,本研究不仅在体内阐明了IFN-γ与细胞焦亡之间的联系,该结果也在体外得到了证实。 讲题: IFN-γ triggers corneal epithelial cell...
研究表明,升高的IFN-γ参与干眼的发病机制,并通过激活JAK2/STAT1信号通路促进角膜上皮焦亡。值得注意的是,本研究不仅在体内阐明了IFN-γ与细胞焦亡之间的联系,该结果也在体外得到了证实。 讲题: IFN-γ triggers corneal epithelial cell pyroptosis and NLRP3 inflammasome via JAK2/STAT1 pathway in dry eye diseas...
结论丹参酮可通过活化JAK2-STAT1通路,上调p-STAT1表达,从而减轻病毒性心肌炎小鼠的心肌损伤。 关键词: 心肌炎;丹参酮 ABSTRACT ObjectiveTo explore the effects of tanshinone and JAK2/STAT1 signaling pathway related mechanism in CVB3-induced myocarditis in murine. MethodsA total of 110 inbred male Balb/c ...
Overall, PRDX6 alleviated HF by inhibiting DOX-induced ferroptosis through the JAK2/STAT1 pathway inactivation.doi:10.1007/s11626-024-00889-0Xiong, JieZhou, RongDeng, XuSpringer USIn Vitro Cellular & Developmental Biology Animal
[4] Tiantian Zhang, et al. SOCS2 Inhibits Mitochondrial Fatty Acid Oxidation via Suppressing LepR/JAK2/AMPK Signaling Pathway in Mouse Adipocytes. Oxid Med Cell Longev. 2020.[5] 郝雨知,蔡啸,金一峰等.基于JAK2/STAT1信号通路探讨骨桥蛋白缓解高血糖大鼠脑出血后炎症反应机制[J].卒中与神经疾病, 2021,...
在哺乳动物中,JAK家族有4个成员(JAK1、JAK2、JAK3、TYK2)和7个STATs(STAT1、STAT2、STAT3、STAT4、STAT5a、STAT5b、STAT6),形成复杂的下游信号通路。由于JAK-STAT通路在RA中发挥重要作用,阻断JAK或STAT激活可抑制炎症反应,延缓RA进展[5]。JAK-STAT...
Stat1 protein positive regulation of tyrosine phosphorylation of Stat3 protein positive regulation of tyrosine phosphorylation of Stat5 protein activation of JAK2 kinase activity regulation of apoptotic process positive regulation of DNA binding negative regulation of DNA binding negative regulation of neuron ...
[4] Tiantian Zhang, et al. SOCS2 Inhibits Mitochondrial Fatty Acid Oxidation via Suppressing LepR/JAK2/AMPK Signaling Pathway in Mouse Adipocytes. Oxid Med Cell Longev. 2020. [5] 郝雨知,蔡啸,金一峰等.基于JAK2/STAT1信号通路探讨骨桥蛋白缓解高血糖大鼠脑出血后炎症反应机制[J].卒中与神经疾病, 2021...
[4] Tiantian Zhang, et al. SOCS2 Inhibits Mitochondrial Fatty Acid Oxidation via Suppressing LepR/JAK2/AMPK Signaling Pathway in Mouse Adipocytes. Oxid Med Cell Longev. 2020. [5] 郝雨知,蔡啸,金一峰等.基于JAK2/STAT1信号通路探讨骨桥蛋白缓解高血糖大鼠脑出血后炎症反应机制[J].卒中与神经疾病, 2021...