它能够结合并促进JAK与STAT分解,在STAT激活时SOCS的快速诱导是决定JAK-STAT信号强度的关键。 其表达缺失与肿瘤细胞PD-L1高表达有关。 PIAS 是细胞因子激活的STAT蛋白抑制物,能够物理阻断核内激活的STAT与DNA结合,从而阻止信号诱导。 PIAS1能够抑制Ⅰ/Ⅱ型IFN→STAT1信号传递,在多种恶心肿瘤中表达升高。 PIAS3被沉默...
它能够结合并促进JAK与STAT分解,在STAT激活时SOCS的快速诱导是决定JAK-STAT信号强度的关键。 其表达缺失与肿瘤细胞PD-L1高表达有关。 PIAS 是细胞因子激活的STAT蛋白抑制物,能够物理阻断核内激活的STAT与DNA结合,从而阻止信号诱导。 PIAS1能够抑制Ⅰ/Ⅱ型IFN→STAT1信号传递,在多...
它能够结合并促进JAK与STAT分解,在STAT激活时SOCS的快速诱导是决定JAK-STAT信号强度的关键。 其表达缺失与肿瘤细胞PD-L1高表达有关。 PIAS 是细胞因子激活的STAT蛋白抑制物,能够物理阻断核内激活的STAT与DNA结合,从而阻止信号诱导。 PIAS1能够抑制Ⅰ/Ⅱ型IFN→STAT1信号传递,在多种恶心肿瘤中表达升高。 PIAS3被沉默...
PD-1PD-L1RuxolitinibSTAT1STAT3Human pancreatic cancer does not respond to immune check point blockade immunotherapy. One key feature of pancreatic cancer is the association between its progression and chronic inflammation. Emerging evidence supports a key role for the JAK-STAT pathway in pancreatic ...
炎症性肠病 (IBD) 通常分为溃疡性结肠炎和克罗恩病,一般以胃肠道慢性炎症为特征。无论分类如何,驱动疾病病理特征的初始机制包括免疫激活、上皮细胞破坏和基质细胞增殖,仍基本未知。然而,一旦疾病确定,细胞因子在疾病的慢性和复发 (急性) 阶段的参与已得到充分证明,针对关...
Moreover, the role of the JAK/STAT pathway in immune evasion by mediating PD-L1/L2 expression has been reported in Hodgkin lymphoma. Chromosome 9p24.1/PD-L1/PD-L2 mutation upregulates PD-1 ligands and PD-L1 on the membrane through JAK/STAT signaling.226,227,228Natural killer/T-cell ...
GC B cells from HIV-1 contaminated individuals express raised degrees of PD-L1 and also have been shown to lessen ICOS and IL-21 expression in Tfh cells upon PD-1 ligation that could additional compromise their capability to provide help B cells [62] ...
The JAK/ STAT pathway is involved in the upregulation of PD-L1 expression in pancreatic cancer cell lines[J]. Oncol Rep, 2017,37(3):1545-1554. (收稿日期:2020-06-04 修回日期:2020-10-27) (编辑:唐晓莲) 《中国药房》杂志——中国科技核心期刊,欢迎投稿,订阅 · 308 · China Pharmacy 2021 ...
Galectin-9 interacts with PD-1 and TIM-3 to regulate T cell death and is a target for cancer immunotherapy. Nat. Commun. 12, 832 (2021). Article CAS PubMed PubMed Central Google Scholar O’Shea, J. J. & Plenge, R. JAK and STAT signaling molecules in immunoregulation and immune-...
PD‐L1 expression is mainly regulated by interferon gamma associated with JAK‐STAT pathway in gastric cancer 来自 科研支点 喜欢 0 阅读量: 182 作者:K Mimura,JL Teh,H Okayama,K Shiraishi,LF Kua,V Koh,DT Smoot,H Ashktorab,T Oike,Y Suzuki ...