Kinase Inhibitor Library The evaluation of the primary outcomes focused on the MCID and PASS scores derived from the KOOS-JR. The study cohort included 254 RA-TKA and 762 C-TKA patients, showing no appreciable distinctions across demographic characteristics like sex, age, body mass index, or ...
Positive topline data from a phase 2 trial show HT-6184, an allosteric NEK7/NLRP3 inflammasome inhibitor, improves hematologic response in lower-risk MDS. Read More Biomarkers and Treatment Strategies in CAR T-Cell Therapy for R/R Multiple Myeloma ...
体外研究 Pyridone 6, a pan-JAK inhibitor, delayed the onset and reduced the magnitude of skin disease in an AD-like skin-disease model of NC/Nga mice. Pyridone 6 displays potent inhibitory activity against JAK1 (IC50=15nM for murine JAK1), JAK2 (IC50=1nM), JAK3 (Ki=5nM), and Tyk2...
体外研究Pyridone 6, a pan-JAK inhibitor, delayed the onset and reduced the magnitude of skin disease in an AD-like skin-disease model of NC/Nga mice. Pyridone 6 displays potent inhibitory activity against JAK1 (IC50=15nM for murine JAK1), JAK2 (IC50=1nM), JAK3 (Ki=5nM), and Tyk2...
The Janus kinase inhibitor JTE-052 improves skin barrier function through suppressing signal transducer and activator of transcription 3 signaling. J. Allergy Clin. Immunol. 136, 667–677.e7 (2015). Article CAS PubMed Google Scholar Bao, L., Shi, V. Y. & Chan, L. S. IL-4 regulates ...
Targeting Stat3 abrogates EGFR inhibitor resistance in cancer. Clin. Cancer Res. 18, 4986–4996 (2012). CAS PubMed PubMed Central Google Scholar Lee, H. J. et al. Drug resistance via feedback activation of Stat3 in oncogene-addicted cancer cells. Cancer Cell 26, 207–221 (2014). CAS...
JAK3 as an emerging target for topical treatment of inflammatory skin diseases PLoS One., 11 (2016), p. e0164080 CrossrefGoogle Scholar 37 L.Y. Liu, B.G. Craiglow, B.A. King Tofacitinib 2% ointment, a topical Janus kinase inhibitor, for the treatment of alopecia areata: A pilot stud...
In 2023, a warning label was placed on JAK inhibitors based on an excess risk for serious heart-related events and cancer reported in rheumatoid arthritis (RA) patients undergoing JAK inhibitor treatment. More studies are necessary to evaluate the safety and efficacy of this approach applied to ...
Inhibitor specificity of MAPK, JAK3/STAT and mTOR signaling pathways in Kit(V560C) and Kit(D816V) mutations found in mastocytosis 来自 ResearchGate 喜欢 0 阅读量: 8 作者:I Chan,MD Tharp 会议名称: Annual Meeting of the Society-for-Investigative-Dermatology ...
A novel JAK inhibitor JTE-052 reduces skin inflammation and ameliorates chronic dermatitis in rodent models: comparison with conventional therapeutic agents[J]. Exp Dermatol, 2018,27(1):22-29. doi: 10.1111/exd.13370 . 返回引文位置Google Scholar 百度学术 万方数据 [23] Amano W , Nakajima S ,...