Blood 140, 2076–2090 (2022). Article CAS PubMed Google Scholar Qin, Y. et al. Age-associated B cells contribute to the pathogenesis of rheumatoid arthritis by inducing activation of fibroblast-like synoviocytes via TNF-α-mediated ERK1/2 and JAK-STAT1 pathways. Ann. Rheum. Dis. 81, ...
Mesenteric vein thrombosis is a rare disorder that is often the first manifestation of a systemic condition such as a hypercoagulable state or cancer. In p... CD Owens - 《Journal of Vascular Surgery》 被引量: 10发表: 2010年 Myeloproliferative disorders with coexisting BCR-ABL translocation and...
Jak-2 gene mutationgastrointestinal bleedingPolycythemia vera is an acquired myeloproliferative disorder that causes overproduction of all three hematopoietic cell lines, most prominently the red blood cells. The most common of the chronic myeloproliferative disorders, polycythemia vera occurs in about 0,5...
STAT3和STAT5的激活与缺血性脑损伤后的神经保护有关,而STAT1的激活与神经元细胞死亡有关,这可能是由于在促凋亡基因caspase-1、caspase-2和caspase-3中存在STAT1结合位点,而在抗凋亡基因B淋巴细胞瘤-2基因 (B-cell lymphoma-2 ,BCL-2) 和重组人B细胞淋巴瘤因子XL (Recombinant Human B-Cell Leukemia/Lymphoma XL...
Dose-dependent increases in blood lipid parameters, specifically LDL cholesterol, have been reported in AD patients treated with abrocitinib, but there was no notable change in LDL cholesterol/HDL cholesterol ratio over 16 weeks; thus, lipid parameters should also be assessed approximately 4 weeks ...
which has to be addressed in the future study. Hemodialysis patients experience sexual dysfunction as a result of the nature of their illness and its own problems. Dialysis clients have reported sexual disorder as one of the most critical stresses, that leads to many psychological and physiological...
- 《Blood》 被引量: 0发表: 2011年 Somatic JAK-2 V617F Mutational Analysis in Polycythemia Rubra Vera: a Tertiary Care Center Experience The rational of this study was to determine the prevalence of the JAK-2 V617F mutation in Pakistani patients with PV. MATERIALS AND METHODS: In this ...
The CD34+ cells were isolated from normal bone marrow and from peripheral blood after G-CSF mobilization. As there was no difference in the expression pattern of the proteins of the JAK/STAT pathway in these two CD34+ populations (data not shown), they were regarded as one group. More ...
JAK-STAT信号传导通路在肿瘤中的进展
Abnormal amplification and recruitment of blood cells lead to hematologic malignancies. The normal actions of the JAK/STAT pathway rely on various components. Thus, basic molecular alterations, such as those caused by gain-of-function mutations in different components (JAK, STAT) and extensive express...