Lipids are shown as grey sticks, with phosphates highlighted as spheres. hNINJ1 protomers are randomly colored yellow, green or purple with the exception of c, where the purple-green-yellow coloring scales with the B-factor (purple low B-factor, yellow large B-factor). Source data...
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Extended data figures and tables Extended Data Fig. 1 Homozygosity of the Ninj1 point mutation correlates with low responsiveness to LPS. a, Ninj1 genotypes and scree...
Clone D1 variable domains were cloned into the human Fab expression vector 1AP39.hIgG1.D.Fab (Genentech). Protein was expressed inE. coliand purified with a low endotoxin level (<0.07 EU mg−1). Pam3CSK4-primed BMDMs were cultured with 50 μg ml−1D1 Fab and then stimulated ...
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Detection of viral DNA can be also performed by qPCR in different biological fluids (blood, urine, CSF), to assess the infection in seronegative subjects and to evidence viral reactivation; notably, though, even in patients with a diagnosis of PML JCPyV viral load can be very low or even ...