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In 1943, Leo Kanner identified the core symptoms of Autism Spectrum Disorder (ASD) in young children [1]. Today, ASD is considered a highly heterogenous and lifelong neurodevelopmental disorder with onset in infancy or early childhood and diagnostic symptoms that include deficits in social communicati...
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Tuberous Sclerosis Complex (TSC) is an autosomal dominant tumor disorder characterized by the growth of hamartomas in various organs including the kidney, brain, skin, lungs, and heart. Rapamycin has been shown to reduce the size of kidney angiomyolipoma
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Microvascular dysfunction (MVD) is an important contributor to major clinical disease such as stroke, dementia, depression, retinopathy, and chronic kidney disease. Alcohol consumption may be a determinant of MVD. Main objectives were (1) to study whethe
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1875Accesses 18Citations 7Altmetric Metrics Abstract In line with the complexity of disease networks, diverse combination therapies have been demonstrated potential in the treatment of different patients with complex diseases in a personal combination profile. However, the identification of rational, compati...
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