今天和大家简单介绍一下孟德尔随机化研究中最常用的两种方法:逆方差加权法(inverse-varianceweighted,IVW)和MR-Egger法。 在讲述之前,我想先和大家介绍一下我们进行MR分析的必要数据,这个数据必须至少包括5列信息:SNP列;暴露的beta值;暴露的se值;结局的beta值;结局的se值。这里的beta值就是SNP对表型(暴露或者结局)...
IVW是最早使用的方法,也是最常用的,它需要SNP完全符合MR研究三原则才能得到正确的因果估计;MR-Egger多加了截距项,其主要目的是判断水平多效性的有无;Weighted Median是利用大部分SNP(majority of genetic variants)来判断因果关系的有无。 接下来是重点部分: 首先推荐使用“MR-PRESSO”包(后面我会简单介绍它的使用...
就像下面这样： # 指定其他方法 result_add_method <- mr(data, method_list = c("mr_ivw",...
The structure of sulphided W/SiO 2 and (Ni,W)/SiO 2 catalysts prepared by various techniques was studied by means of an X-ray method (radial electron distribution technique).In all catalysts after treatment with H 2S at 400掳 the formation of surface species with the structure of WS 2 ...
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has led to an unprecedented analysis of the radial velocities of emission and absorption lines in the close binary system V444 Cyg (WN 5 + O6 III-V... SV Marchenko,AFJ Moffat,G Koenigsberger - 《Astrophysical Journal》 被引量: 69发表: 1994年 The possibly massive symbiotic system V 1329 ...
A. Miller always called the moutn—lies between adoral circlets II and III, being bounded by the two posterior facet-bearing plates and the posterior interradial, i.e. 3 of Adorals II, also by 2 or 3 of Adorals III, making 5 of 6 plates in all. The number 5 is the more usual...
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