TargetGRP78 (Glucose-related protein 78, BiP/HSPA5) is commonly overexpressed in cancer cells. Acting as an activator of endoplasmic reticulum stress, GRP78 is involved in the resistance of cancer cells to injury. Current evidence suggests that GRP78 plays a significant role in the radiotherapy r...
It was a very difficult task, due to its enormous size, consisting of different types of vehicles, rolling stocks, cargo, loco, geographical areas, ghat sections, number of stations, different gauges, electrified and non-electrified sections each having complexities of its own. Gradually all the...
It is thus important to identify and regulate the quantity, composition and transportation of pollutants in offshore regions and their behavior in marine ecosystems. In particular, crucial actions for stabilizing marine ecosystems, including increasing species and biodiversity, should be implemented to ...
All the aforementioned therapies lack broad applicability and/or effectiveness, with only a small subset of patients achieving durable responses. Efforts to understand which parameters drive therapy success or failure in individual patients or tumour entities are ongoing, and multiple studies are unravellin...
Mitochondrial metabolism has been shown to play a key role in immune cell survival and function, but mitochondrial creatine kinase 2 (CKMT2) has been relatively little studied about tumor immunity. We aimed to explore the prognostic value of CKMT2 in 33
Ascorbic acid (AA; vitamin C) plays a crucial role in the biosynthesis and secretion of collagen to produce the organic matrix of hard tissues. Nevertheless, the detailed mechanism by which AA induces reparative dentinogenesis is still unknown. This stud
The adaptation of the SITES framework in China was further examined through assessing its effectiveness in evaluating representative Chinese landscape projects. Therefore, we conducted a case study focusing on the Beijing Central Green Forest Park, a landmark example of Chinese sustainable green area ...
DARZALEX FASPRO® (daratumumab and hyaluronidase-fihj) received U.S. FDA approval in May 2020 and is approved for eight indications in multiple myeloma, three of which are for frontline treatment in newly diagnosed patients who are ...
It is important to improve the efficiency of brain-targeted delivery of drugs. (2) Researchers should identify and evaluate the factors that affect the behavior of the glioma NDDS in vivo, which is the basis of the effectiveness. (3) Considering the perspective of biosafety, b...
Thus, it was applied in the polymer, coating as well as in the packaging industry. The study deals with the extraction, properties, and application of eugenol as raw material, in the packaging and the coating industry. Various extraction methods of eugenol have been discussed as conventional, ...