The OL plasmid expressing the truncation of ITGB2-AS1, which was complementary to ITGB2, was essential for activation of FAK signaling. In conclusion, LncRNA ITGB2-AS1 could promote the migration and invasion of breast cancer cells by up-regulating ITGB2. 展开 关键词: lncRNA ITGB2-AS1 IT...
The expression levels of ITGB2-AS1 were up-regulated in osteosarcoma tissue samples and cell lines determined by qRT-PCR assay. Osteosarcoma patients with high ITGB2-AS1 expression had a significantly poor prognosis. In addition, knockdown of ITGB2-AS1 inhibited the proliferation and induced ...
临床上,ITGB2-AS1高表达与较大的年龄(P=0.023)和较低的完全缓解(CR)率(P =0.005)相关.多变量分析发现,高ITGB2-AS1表达是CR率(P =0.027)和总体生存时间(0S)(P=0.011)的独立预后因素,ITGB2-AS1在TCGA数据集(r=0.74,P<0.001)和本研究患者数据中(r=0.881,P<0.001)均与ITGB2表达正相关.高ITGB2表达也...
The lncRNA integrin subunit beta 2 (ITGB2)-anti-sense RNA 1 (ITGB2-AS1) affectsITGB2expression; however, there is a gap in knowledge regarding its expression and clinical usefulness in RA and OA. This study investigated the potential of serumITGB2-AS1as a novel diagnostic biomarker and its...
LncRNA ITGB2-AS1 promotes cisplatin resistance of non-small cell lung cancer by inhibiting ferroptosis via activating the FOSL2/NAMPT axisHuiyong ChenLinhui WangJingting LiuZihao WanLin ZhouHongliang LiaoRenping Wan
To further explore its role in eosinophil biology, we generated a stable ITGB2-AS1 knockdown in the HL-60 cell line. Interestingly, ITGB2-AS1 deficiency led to impaired eosinophil differentiation, as evidenced by a reduction in cytoplasmic granules and decreased expression of key eosinophil granule...
In conclusion, LncRNA ITGB2-AS1 could promote the migration and invasion of breast cancer cells by up-regulating ITGB2. Keywords: lncRNA; ITGB2-AS1; ITGB2; breast cancer; migration; invasion 1. Introduction Cancer is the second leading cause of death after cardiovascular diseases [1], and ...