The Isosorbide Mononitrate Extended-Release Tablet is an oral extended-release formulation of ISMN, the major active metabolite of isosorbide dinitrate; most of the clinical activity of the dinitrate is attributable to the mononitrate. The principal pharmacological action of ISMN and all organic nitrates...
Stepanovi Petrovi RM, Toki Vujosevi Z, Milovanovi S, Cekovi Z, Bokonji D, Dobri S: Pharmacological evaluation of a novel oxime derived from isosorbide-5-mononitrate on isolated rat superior mesenteric artery. Pharmazie 57(7), 507-508 (2002)...
Isosorbide dinitrateundergoes extensive first-pass metabolism in the liver and is cleared at a rate of 2 to 4 L/minute with a serum half-life of about 1 hour. Isosorbide dinitrate's clearance is primarily by denitration to the 2-mononitrate (15 to 25%) and the 5-mononitrate (75 to 85%...