isosorbide mononitratevirtual bioequivalence studyphysiologically based pharmacokinetic modelB2O simulatorAim The waiver of bioequivalence (BE) studies is well accepted for Biopharmaceutics Classification System (BCS) class I drugs in form of immediate-release solid oral products. This study aimed to assess...
Isosorbide 5-mononitratecas:16051-77-7 ISOSORBIDE DIMETHYL ETHERcas:5306-85-4 ISOSORBIDE 2-MONONITRATEcas:16106-20-0 D-ISOSORBIDE DINITRATEcas:8063-88-51. Names and Identifiers 2. Properties 3. Use and Manufacturing 4. Safety and Handling 5. Msds 6. NMR Spectrum 7. Synthesis Route 8. Precu...
Isosorbide dinitrateundergoes extensive first-pass metabolism in the liver and is cleared at a rate of 2 to 4 L/minute with a serum half-life of about 1 hour. Isosorbide dinitrate's clearance is primarily by denitration to the 2-mononitrate (15 to 25%) and the 5-mononitrate (75 to 85%...